The optimal glycemic target in critically ill patients: an updated network meta-analysis
Abstract Acute glycemic control significantly affects the clinical outcomes of critically ill patients. This updated network meta-analysis examines the benefits and harms of four target blood glucose levels (< 110, 110–144, 144–180, and > 180 mg/dL). Analyzing data of 27,541 patients from 37 t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Intensive Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40560-024-00728-0 |
| _version_ | 1797199601368825856 |
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| author | Aiko Tanaka Tomoaki Yatabe Tomohiro Suhara Moritoki Egi |
| author_facet | Aiko Tanaka Tomoaki Yatabe Tomohiro Suhara Moritoki Egi |
| author_sort | Aiko Tanaka |
| collection | DOAJ |
| description | Abstract Acute glycemic control significantly affects the clinical outcomes of critically ill patients. This updated network meta-analysis examines the benefits and harms of four target blood glucose levels (< 110, 110–144, 144–180, and > 180 mg/dL). Analyzing data of 27,541 patients from 37 trials, the surface under the cumulative ranking curve for mortality and hypoglycemia was highest at a target blood glucose level of 144–180 mg/dL, while for infection and acute kidney injury at 110–144 mg/dL. Further evidence is needed to determine whether 110–144 or 144–180 mg/dL is superior as an optimal glucose target, considering prioritized outcomes. |
| first_indexed | 2024-04-24T07:18:21Z |
| format | Article |
| id | doaj.art-474346d6014140e5b87adae194c90c79 |
| institution | Directory Open Access Journal |
| issn | 2052-0492 |
| language | English |
| last_indexed | 2024-04-24T07:18:21Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Intensive Care |
| spelling | doaj.art-474346d6014140e5b87adae194c90c792024-04-21T11:10:30ZengBMCJournal of Intensive Care2052-04922024-04-011211510.1186/s40560-024-00728-0The optimal glycemic target in critically ill patients: an updated network meta-analysisAiko Tanaka0Tomoaki Yatabe1Tomohiro Suhara2Moritoki Egi3Department of Intensive Care, University of Fukui HospitalEmergency Department, Nishichita General HospitalDepartment of Anesthesiology, Keio University School of MedicineDepartment of Anesthesia, Kyoto University HospitalAbstract Acute glycemic control significantly affects the clinical outcomes of critically ill patients. This updated network meta-analysis examines the benefits and harms of four target blood glucose levels (< 110, 110–144, 144–180, and > 180 mg/dL). Analyzing data of 27,541 patients from 37 trials, the surface under the cumulative ranking curve for mortality and hypoglycemia was highest at a target blood glucose level of 144–180 mg/dL, while for infection and acute kidney injury at 110–144 mg/dL. Further evidence is needed to determine whether 110–144 or 144–180 mg/dL is superior as an optimal glucose target, considering prioritized outcomes.https://doi.org/10.1186/s40560-024-00728-0Glycemic controlBlood glucoseOptimal targetCritical careNetwork meta-analysis |
| spellingShingle | Aiko Tanaka Tomoaki Yatabe Tomohiro Suhara Moritoki Egi The optimal glycemic target in critically ill patients: an updated network meta-analysis Journal of Intensive Care Glycemic control Blood glucose Optimal target Critical care Network meta-analysis |
| title | The optimal glycemic target in critically ill patients: an updated network meta-analysis |
| title_full | The optimal glycemic target in critically ill patients: an updated network meta-analysis |
| title_fullStr | The optimal glycemic target in critically ill patients: an updated network meta-analysis |
| title_full_unstemmed | The optimal glycemic target in critically ill patients: an updated network meta-analysis |
| title_short | The optimal glycemic target in critically ill patients: an updated network meta-analysis |
| title_sort | optimal glycemic target in critically ill patients an updated network meta analysis |
| topic | Glycemic control Blood glucose Optimal target Critical care Network meta-analysis |
| url | https://doi.org/10.1186/s40560-024-00728-0 |
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