Applications and Mechanisms of Tripterygium Wilfordii Hook. F. and its Preparations in Kidney Diseases
Tripterygium wilfordii Hook. f. (TwHF) is a Chinese botanical drug containing a large number of metabolites. The discovered and recognized anti-inflammatory and immune-regulating effects have made it attract more and more attentions in trials and clinical researches. The extraction and processing of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.846746/full |
| _version_ | 1818442456164728832 |
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| author | Xue Tong Xue Tong Xue Tong Yanheng Qiao Yanheng Qiao Yuanjian Yang Haizhao Liu Zhiyong Cao Bo Yang Bo Yang Lijuan Wei Lijuan Wei Hongtao Yang Hongtao Yang |
| author_facet | Xue Tong Xue Tong Xue Tong Yanheng Qiao Yanheng Qiao Yuanjian Yang Haizhao Liu Zhiyong Cao Bo Yang Bo Yang Lijuan Wei Lijuan Wei Hongtao Yang Hongtao Yang |
| author_sort | Xue Tong |
| collection | DOAJ |
| description | Tripterygium wilfordii Hook. f. (TwHF) is a Chinese botanical drug containing a large number of metabolites. The discovered and recognized anti-inflammatory and immune-regulating effects have made it attract more and more attentions in trials and clinical researches. The extraction and processing of TwHF for pharmaceuticals is a manifestation of the role of traditional Chinese medicine. However, TwHF is toxic. Optimization of TwHF preparations has become a requirement for the development of TwHF pharmaceuticals. Our article introduces the main preparations of TwHF on the Chinese market and their characteristics. In particular, we summarize the clinical applications and influential mechanisms of TwHF and its preparations in kidney diseases. Considering that nephropathy is closely related to immune inflammation and TwHF is a botanical drug with a high number of metabolites, the application of TwHF in kidney diseases may be much more complicated. By revealing the role and mechanisms of TwHF in kidney diseases, this study aims to provide more insights to basic and clinical studies about nephropathy. |
| first_indexed | 2024-12-14T18:44:26Z |
| format | Article |
| id | doaj.art-47436fc98c714df4a99a1a4652462538 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-14T18:44:26Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-47436fc98c714df4a99a1a46524625382022-12-21T22:51:24ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-03-011310.3389/fphar.2022.846746846746Applications and Mechanisms of Tripterygium Wilfordii Hook. F. and its Preparations in Kidney DiseasesXue Tong0Xue Tong1Xue Tong2Yanheng Qiao3Yanheng Qiao4Yuanjian Yang5Haizhao Liu6Zhiyong Cao7Bo Yang8Bo Yang9Lijuan Wei10Lijuan Wei11Hongtao Yang12Hongtao Yang13Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaTianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaTianjin Jinnan Traditional Chinese Medicine Hospital, Tianjin, ChinaTianjin University of Traditional Chinese Medicine, Tianjin, ChinaTianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaTripterygium wilfordii Hook. f. (TwHF) is a Chinese botanical drug containing a large number of metabolites. The discovered and recognized anti-inflammatory and immune-regulating effects have made it attract more and more attentions in trials and clinical researches. The extraction and processing of TwHF for pharmaceuticals is a manifestation of the role of traditional Chinese medicine. However, TwHF is toxic. Optimization of TwHF preparations has become a requirement for the development of TwHF pharmaceuticals. Our article introduces the main preparations of TwHF on the Chinese market and their characteristics. In particular, we summarize the clinical applications and influential mechanisms of TwHF and its preparations in kidney diseases. Considering that nephropathy is closely related to immune inflammation and TwHF is a botanical drug with a high number of metabolites, the application of TwHF in kidney diseases may be much more complicated. By revealing the role and mechanisms of TwHF in kidney diseases, this study aims to provide more insights to basic and clinical studies about nephropathy.https://www.frontiersin.org/articles/10.3389/fphar.2022.846746/fulltripterygium wilfordii hook. f.tripterygium wilfordii hook. f. preparationskidney diseasesclinical applicationsmechanismstoxicity |
| spellingShingle | Xue Tong Xue Tong Xue Tong Yanheng Qiao Yanheng Qiao Yuanjian Yang Haizhao Liu Zhiyong Cao Bo Yang Bo Yang Lijuan Wei Lijuan Wei Hongtao Yang Hongtao Yang Applications and Mechanisms of Tripterygium Wilfordii Hook. F. and its Preparations in Kidney Diseases Frontiers in Pharmacology tripterygium wilfordii hook. f. tripterygium wilfordii hook. f. preparations kidney diseases clinical applications mechanisms toxicity |
| title | Applications and Mechanisms of Tripterygium Wilfordii Hook. F. and its Preparations in Kidney Diseases |
| title_full | Applications and Mechanisms of Tripterygium Wilfordii Hook. F. and its Preparations in Kidney Diseases |
| title_fullStr | Applications and Mechanisms of Tripterygium Wilfordii Hook. F. and its Preparations in Kidney Diseases |
| title_full_unstemmed | Applications and Mechanisms of Tripterygium Wilfordii Hook. F. and its Preparations in Kidney Diseases |
| title_short | Applications and Mechanisms of Tripterygium Wilfordii Hook. F. and its Preparations in Kidney Diseases |
| title_sort | applications and mechanisms of tripterygium wilfordii hook f and its preparations in kidney diseases |
| topic | tripterygium wilfordii hook. f. tripterygium wilfordii hook. f. preparations kidney diseases clinical applications mechanisms toxicity |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.846746/full |
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