Oxidative Stress, Plant Natural Antioxidants, and Obesity
Oxidative stress is important in the pathophysiology of obesity, altering regulatory factors of mitochondrial activity, modifying the concentration of inflammation mediators associated with a large number and size of adipocytes, promoting lipogenesis, stimulating differentiation of preadipocytes to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/4/1786 |
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| author | Israel Pérez-Torres Vicente Castrejón-Téllez María Elena Soto María Esther Rubio-Ruiz Linaloe Manzano-Pech Verónica Guarner-Lans |
| author_facet | Israel Pérez-Torres Vicente Castrejón-Téllez María Elena Soto María Esther Rubio-Ruiz Linaloe Manzano-Pech Verónica Guarner-Lans |
| author_sort | Israel Pérez-Torres |
| collection | DOAJ |
| description | Oxidative stress is important in the pathophysiology of obesity, altering regulatory factors of mitochondrial activity, modifying the concentration of inflammation mediators associated with a large number and size of adipocytes, promoting lipogenesis, stimulating differentiation of preadipocytes to mature adipocytes, and regulating the energy balance in hypothalamic neurons that control appetite. This review discusses the participation of oxidative stress in obesity and the important groups of compounds found in plants with antioxidant properties, which include (a) polyphenols such as phenolic acids, stilbenes, flavonoids (flavonols, flavanols, anthocyanins, flavanones, flavones, flavanonols, and isoflavones), and curcuminoids (b) carotenoids, (c) capsaicinoids and casinoids, (d) isothiocyanates, (e) catechins, and (f) vitamins. Examples are analyzed, such as resveratrol, quercetin, curcumin, ferulic acid, phloretin, green tea, Hibiscus Sabdariffa, and garlic. The antioxidant activities of these compounds depend on their activities as reactive oxygen species (ROS) scavengers and on their capacity to prevent the activation of NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells), and reduce the expression of target genes, including those participating in inflammation. We conclude that natural compounds have therapeutic potential for diseases mediated by oxidative stress, particularly obesity. Controlled and well-designed clinical trials are still necessary to better know the effects of these compounds. |
| first_indexed | 2024-03-09T04:45:49Z |
| format | Article |
| id | doaj.art-47437660b43a4b3b9c00385a17f32da9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:45:49Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-47437660b43a4b3b9c00385a17f32da92023-12-03T13:15:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224178610.3390/ijms22041786Oxidative Stress, Plant Natural Antioxidants, and ObesityIsrael Pérez-Torres0Vicente Castrejón-Téllez1María Elena Soto2María Esther Rubio-Ruiz3Linaloe Manzano-Pech4Verónica Guarner-Lans5Department of Molecular Biomedicine, Instituto Nacional de Cardiología “Ignacio Chavez”, Tlalpan 14080, MexicoDepartment of Physiology, Instituto Nacional de Cardiología “Ignacio Chavez”, Tlalpan 14080, MexicoDepartment of Immunology, Instituto Nacional de Cardiología “Ignacio Chavez”, Tlalpan 14080, MexicoDepartment of Physiology, Instituto Nacional de Cardiología “Ignacio Chavez”, Tlalpan 14080, MexicoDepartment of Molecular Biomedicine, Instituto Nacional de Cardiología “Ignacio Chavez”, Tlalpan 14080, MexicoDepartment of Physiology, Instituto Nacional de Cardiología “Ignacio Chavez”, Tlalpan 14080, MexicoOxidative stress is important in the pathophysiology of obesity, altering regulatory factors of mitochondrial activity, modifying the concentration of inflammation mediators associated with a large number and size of adipocytes, promoting lipogenesis, stimulating differentiation of preadipocytes to mature adipocytes, and regulating the energy balance in hypothalamic neurons that control appetite. This review discusses the participation of oxidative stress in obesity and the important groups of compounds found in plants with antioxidant properties, which include (a) polyphenols such as phenolic acids, stilbenes, flavonoids (flavonols, flavanols, anthocyanins, flavanones, flavones, flavanonols, and isoflavones), and curcuminoids (b) carotenoids, (c) capsaicinoids and casinoids, (d) isothiocyanates, (e) catechins, and (f) vitamins. Examples are analyzed, such as resveratrol, quercetin, curcumin, ferulic acid, phloretin, green tea, Hibiscus Sabdariffa, and garlic. The antioxidant activities of these compounds depend on their activities as reactive oxygen species (ROS) scavengers and on their capacity to prevent the activation of NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells), and reduce the expression of target genes, including those participating in inflammation. We conclude that natural compounds have therapeutic potential for diseases mediated by oxidative stress, particularly obesity. Controlled and well-designed clinical trials are still necessary to better know the effects of these compounds.https://www.mdpi.com/1422-0067/22/4/1786oxidative stressobesityantioxidantsnatural products |
| spellingShingle | Israel Pérez-Torres Vicente Castrejón-Téllez María Elena Soto María Esther Rubio-Ruiz Linaloe Manzano-Pech Verónica Guarner-Lans Oxidative Stress, Plant Natural Antioxidants, and Obesity International Journal of Molecular Sciences oxidative stress obesity antioxidants natural products |
| title | Oxidative Stress, Plant Natural Antioxidants, and Obesity |
| title_full | Oxidative Stress, Plant Natural Antioxidants, and Obesity |
| title_fullStr | Oxidative Stress, Plant Natural Antioxidants, and Obesity |
| title_full_unstemmed | Oxidative Stress, Plant Natural Antioxidants, and Obesity |
| title_short | Oxidative Stress, Plant Natural Antioxidants, and Obesity |
| title_sort | oxidative stress plant natural antioxidants and obesity |
| topic | oxidative stress obesity antioxidants natural products |
| url | https://www.mdpi.com/1422-0067/22/4/1786 |
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