Breaking the circulus vitiosus of neuroinflammation: Resveratrol attenuates the human glial cell response to cytokines
Neuroinflammation is both cause and effect of many neurodegenerative disorders. Activation of astrocytes and microglia leads to the release of cytokines and reactive oxygen species followed by blood-brain barrier leakage and neurotoxicity. Transient neuroinflammation is considered to be largely prot...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223006042 |
| _version_ | 1797822111040929792 |
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| author | Luise Schlotterose François Cossais Ralph Lucius Kirsten Hattermann |
| author_facet | Luise Schlotterose François Cossais Ralph Lucius Kirsten Hattermann |
| author_sort | Luise Schlotterose |
| collection | DOAJ |
| description | Neuroinflammation is both cause and effect of many neurodegenerative disorders. Activation of astrocytes and microglia leads to the release of cytokines and reactive oxygen species followed by blood-brain barrier leakage and neurotoxicity. Transient neuroinflammation is considered to be largely protective, however, chronic neuroinflammation contributes to the pathology of Alzheimer’s disease, multiple sclerosis, traumatic brain injury, and many more. In this study, we focus on the aspect of cytokine-induced neuroinflammation in human microglia and astrocytes. Here we show by mRNA and protein analysis that cytokines, released not only by microglia but also by astrocytes, lead to a circuit of proinflammatory activation. Moreover, we present how the natural compound resveratrol can stop the circuit of proinflammatory activation and facilitate return to resting conditions. These results will contribute to distinguishing between the causes and the effects of neuroinflammation, a better understanding of underlying mechanisms, and potential treatment options. |
| first_indexed | 2024-03-13T10:03:03Z |
| format | Article |
| id | doaj.art-4744b2dbc0ab4d06a2ba825a07b1a0fc |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T10:03:03Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-4744b2dbc0ab4d06a2ba825a07b1a0fc2023-05-23T04:21:10ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-07-01163114814Breaking the circulus vitiosus of neuroinflammation: Resveratrol attenuates the human glial cell response to cytokinesLuise Schlotterose0François Cossais1Ralph Lucius2Kirsten Hattermann3Institute of Anatomy, Kiel University, 24118 Kiel, GermanyInstitute of Anatomy, Kiel University, 24118 Kiel, GermanyInstitute of Anatomy, Kiel University, 24118 Kiel, GermanyCorresponding author.; Institute of Anatomy, Kiel University, 24118 Kiel, GermanyNeuroinflammation is both cause and effect of many neurodegenerative disorders. Activation of astrocytes and microglia leads to the release of cytokines and reactive oxygen species followed by blood-brain barrier leakage and neurotoxicity. Transient neuroinflammation is considered to be largely protective, however, chronic neuroinflammation contributes to the pathology of Alzheimer’s disease, multiple sclerosis, traumatic brain injury, and many more. In this study, we focus on the aspect of cytokine-induced neuroinflammation in human microglia and astrocytes. Here we show by mRNA and protein analysis that cytokines, released not only by microglia but also by astrocytes, lead to a circuit of proinflammatory activation. Moreover, we present how the natural compound resveratrol can stop the circuit of proinflammatory activation and facilitate return to resting conditions. These results will contribute to distinguishing between the causes and the effects of neuroinflammation, a better understanding of underlying mechanisms, and potential treatment options.http://www.sciencedirect.com/science/article/pii/S0753332223006042NeuroinflammationNeurodegenerative diseasesAstrocytesMicrogliaTNFαECM proteins |
| spellingShingle | Luise Schlotterose François Cossais Ralph Lucius Kirsten Hattermann Breaking the circulus vitiosus of neuroinflammation: Resveratrol attenuates the human glial cell response to cytokines Biomedicine & Pharmacotherapy Neuroinflammation Neurodegenerative diseases Astrocytes Microglia TNFα ECM proteins |
| title | Breaking the circulus vitiosus of neuroinflammation: Resveratrol attenuates the human glial cell response to cytokines |
| title_full | Breaking the circulus vitiosus of neuroinflammation: Resveratrol attenuates the human glial cell response to cytokines |
| title_fullStr | Breaking the circulus vitiosus of neuroinflammation: Resveratrol attenuates the human glial cell response to cytokines |
| title_full_unstemmed | Breaking the circulus vitiosus of neuroinflammation: Resveratrol attenuates the human glial cell response to cytokines |
| title_short | Breaking the circulus vitiosus of neuroinflammation: Resveratrol attenuates the human glial cell response to cytokines |
| title_sort | breaking the circulus vitiosus of neuroinflammation resveratrol attenuates the human glial cell response to cytokines |
| topic | Neuroinflammation Neurodegenerative diseases Astrocytes Microglia TNFα ECM proteins |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223006042 |
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