The IRE1α–XBP1s Arm of the Unfolded Protein Response Activates N-Glycosylation to Remodel the Subepithelial Basement Membrane in Paramyxovirus Infection

The IRE1α–XBP1s Arm of the Unfolded Protein Response Activates N-Glycosylation to Remodel the Subepithelial Basement Membrane in Paramyxovirus Infection

Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections (LRTI) associated with decreased pulmonary function, asthma, and allergy. Recently, we demonstrated that RSV induces the hexosamine biosynthetic pathway via the unfolded protein response (UPR), which is a pathway cont...

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Bibliographic Details
Main Authors: Yingxin Zhao, Dianhua Qiao, Melissa Skibba, Allan R. Brasier
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
unfolded protein response
IRE1α
XBP1
hexosamine biosynthetic pathway
N-glycosylation
extracellular matrix
Online Access:https://www.mdpi.com/1422-0067/23/16/9000

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