Full cervical cord tractography: A new method for clinical use
Despite recent improvements in diffusion-weighted imaging, spinal cord tractography is not used in routine clinical practice because of difficulties in reconstructing tractograms, with a pertinent tri-dimensional-rendering, in a long post-processing time. We propose a new full tractography approach...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnana.2022.993464/full |
| _version_ | 1828227936188104704 |
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| author | Corentin Dauleac Corentin Dauleac Corentin Dauleac Carole Frindel Carole Frindel Isabelle Pélissou-Guyotat Célia Nicolas Fang-Cheng Yeh Juan Fernandez-Miranda François Cotton François Cotton François Cotton Timothée Jacquesson Timothée Jacquesson Timothée Jacquesson |
| author_facet | Corentin Dauleac Corentin Dauleac Corentin Dauleac Carole Frindel Carole Frindel Isabelle Pélissou-Guyotat Célia Nicolas Fang-Cheng Yeh Juan Fernandez-Miranda François Cotton François Cotton François Cotton Timothée Jacquesson Timothée Jacquesson Timothée Jacquesson |
| author_sort | Corentin Dauleac |
| collection | DOAJ |
| description | Despite recent improvements in diffusion-weighted imaging, spinal cord tractography is not used in routine clinical practice because of difficulties in reconstructing tractograms, with a pertinent tri-dimensional-rendering, in a long post-processing time. We propose a new full tractography approach to the cervical spinal cord without extensive manual filtering or multiple regions of interest seeding that could help neurosurgeons manage various spinal cord disorders. Four healthy volunteers and two patients with either cervical intramedullary tumors or spinal cord injuries were included. Diffusion-weighted images of the cervical spinal cord were acquired using a Philips 3 Tesla machine, 32 diffusion directions, 1,000 s/mm2b-value, 2 × 2 × 2 mm voxel size, reduced field-of-view (ZOOM), with two opposing phase-encoding directions. Distortion corrections were then achieved using the FSL software package, and tracking of the full cervical spinal cord was performed using the DSI Studio software (quantitative anisotropy-based deterministic algorithm). A unique region of avoidance was used to exclude everything that is not of the nervous system. Fiber tracking parameters used adaptative fractional anisotropy from 0.015 to 0.045, fiber length from 10 to 1,000 mm, and angular threshold of 90°. In all participants, a full cervical cord tractography was performed from the medulla to the C7 spine level. On a ventral view, the junction between the medulla and spinal cord was identified with its pyramidal bulging, and by an invagination corresponding to the median ventral sulcus. On a dorsal view, the fourth ventricle—superior, middle, and inferior cerebellar peduncles—was seen, as well as its floor and the obex; and gracile and cuneate tracts were recognized on each side of the dorsal median sulcus. In the case of the intramedullary tumor or spinal cord injury, the spinal tracts were seen to be displaced, and this helped to adjust the neurosurgical strategy. This new full tractography approach simplifies the tractography pipeline and provides a reliable 3D-rendering of the spinal cord that could help to adjust the neurosurgical strategy. |
| first_indexed | 2024-04-12T18:13:52Z |
| format | Article |
| id | doaj.art-47461dc90264485294b99ce0dd583003 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-04-12T18:13:52Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-47461dc90264485294b99ce0dd5830032022-12-22T03:21:42ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292022-09-011610.3389/fnana.2022.993464993464Full cervical cord tractography: A new method for clinical useCorentin Dauleac0Corentin Dauleac1Corentin Dauleac2Carole Frindel3Carole Frindel4Isabelle Pélissou-Guyotat5Célia Nicolas6Fang-Cheng Yeh7Juan Fernandez-Miranda8François Cotton9François Cotton10François Cotton11Timothée Jacquesson12Timothée Jacquesson13Timothée Jacquesson14Service de Neurochirurgie, Hôpital neurologique et neurochirurgical Pierre Wertheimer, Hospices Civils de Lyon, Lyon, FranceLaboratoire CREATIS, CNRS UMR5220, Inserm U1206, INSA-Lyon, Villeurbanne, FranceUniversité de Lyon I, Lyon, FranceLaboratoire CREATIS, CNRS UMR5220, Inserm U1206, INSA-Lyon, Villeurbanne, FranceUniversité de Lyon I, Lyon, FranceService de Neurochirurgie, Hôpital neurologique et neurochirurgical Pierre Wertheimer, Hospices Civils de Lyon, Lyon, FranceHospices Civils de Lyon, Centre Hospitalier de Lyon Sud, Service de Radiologie, Lyon, FranceDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesDepartment of Neurosurgery, Stanford University Medical Center, Stanford, CA, United StatesLaboratoire CREATIS, CNRS UMR5220, Inserm U1206, INSA-Lyon, Villeurbanne, FranceUniversité de Lyon I, Lyon, FranceHospices Civils de Lyon, Centre Hospitalier de Lyon Sud, Service de Radiologie, Lyon, FranceService de Neurochirurgie, Hôpital neurologique et neurochirurgical Pierre Wertheimer, Hospices Civils de Lyon, Lyon, FranceLaboratoire CREATIS, CNRS UMR5220, Inserm U1206, INSA-Lyon, Villeurbanne, FranceUniversité de Lyon I, Lyon, FranceDespite recent improvements in diffusion-weighted imaging, spinal cord tractography is not used in routine clinical practice because of difficulties in reconstructing tractograms, with a pertinent tri-dimensional-rendering, in a long post-processing time. We propose a new full tractography approach to the cervical spinal cord without extensive manual filtering or multiple regions of interest seeding that could help neurosurgeons manage various spinal cord disorders. Four healthy volunteers and two patients with either cervical intramedullary tumors or spinal cord injuries were included. Diffusion-weighted images of the cervical spinal cord were acquired using a Philips 3 Tesla machine, 32 diffusion directions, 1,000 s/mm2b-value, 2 × 2 × 2 mm voxel size, reduced field-of-view (ZOOM), with two opposing phase-encoding directions. Distortion corrections were then achieved using the FSL software package, and tracking of the full cervical spinal cord was performed using the DSI Studio software (quantitative anisotropy-based deterministic algorithm). A unique region of avoidance was used to exclude everything that is not of the nervous system. Fiber tracking parameters used adaptative fractional anisotropy from 0.015 to 0.045, fiber length from 10 to 1,000 mm, and angular threshold of 90°. In all participants, a full cervical cord tractography was performed from the medulla to the C7 spine level. On a ventral view, the junction between the medulla and spinal cord was identified with its pyramidal bulging, and by an invagination corresponding to the median ventral sulcus. On a dorsal view, the fourth ventricle—superior, middle, and inferior cerebellar peduncles—was seen, as well as its floor and the obex; and gracile and cuneate tracts were recognized on each side of the dorsal median sulcus. In the case of the intramedullary tumor or spinal cord injury, the spinal tracts were seen to be displaced, and this helped to adjust the neurosurgical strategy. This new full tractography approach simplifies the tractography pipeline and provides a reliable 3D-rendering of the spinal cord that could help to adjust the neurosurgical strategy.https://www.frontiersin.org/articles/10.3389/fnana.2022.993464/fullspinal cordtractographyfiber orientation distributionfiber trackingdiffusion tensor (DT) MRI |
| spellingShingle | Corentin Dauleac Corentin Dauleac Corentin Dauleac Carole Frindel Carole Frindel Isabelle Pélissou-Guyotat Célia Nicolas Fang-Cheng Yeh Juan Fernandez-Miranda François Cotton François Cotton François Cotton Timothée Jacquesson Timothée Jacquesson Timothée Jacquesson Full cervical cord tractography: A new method for clinical use Frontiers in Neuroanatomy spinal cord tractography fiber orientation distribution fiber tracking diffusion tensor (DT) MRI |
| title | Full cervical cord tractography: A new method for clinical use |
| title_full | Full cervical cord tractography: A new method for clinical use |
| title_fullStr | Full cervical cord tractography: A new method for clinical use |
| title_full_unstemmed | Full cervical cord tractography: A new method for clinical use |
| title_short | Full cervical cord tractography: A new method for clinical use |
| title_sort | full cervical cord tractography a new method for clinical use |
| topic | spinal cord tractography fiber orientation distribution fiber tracking diffusion tensor (DT) MRI |
| url | https://www.frontiersin.org/articles/10.3389/fnana.2022.993464/full |
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