Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China
Leptospirosis is a global zoonotic disease caused by pathogenic Leptospira, and those infected animals will show a variety of clinical symptoms and even death. The discovery of endemic strains is crucial to produce effective vaccines. In this study, we report that a strain of Leptospira, isolated fr...
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| Format: | Article |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2020.607115/full |
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| author | Ning Song Wenlong Zhang Yue Ding Dianjun Wu Zonghao Dai Li Xu Yongguo Cao |
| author_facet | Ning Song Wenlong Zhang Yue Ding Dianjun Wu Zonghao Dai Li Xu Yongguo Cao |
| author_sort | Ning Song |
| collection | DOAJ |
| description | Leptospirosis is a global zoonotic disease caused by pathogenic Leptospira, and those infected animals will show a variety of clinical symptoms and even death. The discovery of endemic strains is crucial to produce effective vaccines. In this study, we report that a strain of Leptospira, isolated from a dog, is pathogenic. Using MLST analysis, the serovar of isolated Leptospira was identified and found it belongs to Leptospira interrogation Serovar Australis. Then, the virulence of this strain was researched by using hamsters. After infection, all the hamsters died within 4–5 days. Typical pathological changes were found in the liver, kidney, and lung of hamsters. These results all indicated that the isolated Leptospira was pathogenic. Thus, this study facilitates to identifying local Leptospira strains and develop a more targeted canine Leptospira vaccine. |
| first_indexed | 2024-04-12T22:12:52Z |
| format | Article |
| id | doaj.art-474684398f6049a7a53a8802acdaed9d |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-12T22:12:52Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-474684398f6049a7a53a8802acdaed9d2022-12-22T03:14:39ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692021-01-01710.3389/fvets.2020.607115607115Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, ChinaNing Song0Wenlong Zhang1Yue Ding2Dianjun Wu3Zonghao Dai4Li Xu5Yongguo Cao6Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaNanchang Police Dog Base of the Ministry of Public Security, Nanchang, ChinaNanchang Police Dog Base of the Ministry of Public Security, Nanchang, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaLeptospirosis is a global zoonotic disease caused by pathogenic Leptospira, and those infected animals will show a variety of clinical symptoms and even death. The discovery of endemic strains is crucial to produce effective vaccines. In this study, we report that a strain of Leptospira, isolated from a dog, is pathogenic. Using MLST analysis, the serovar of isolated Leptospira was identified and found it belongs to Leptospira interrogation Serovar Australis. Then, the virulence of this strain was researched by using hamsters. After infection, all the hamsters died within 4–5 days. Typical pathological changes were found in the liver, kidney, and lung of hamsters. These results all indicated that the isolated Leptospira was pathogenic. Thus, this study facilitates to identifying local Leptospira strains and develop a more targeted canine Leptospira vaccine.https://www.frontiersin.org/articles/10.3389/fvets.2020.607115/fullLeptospira interrogans Serovar AustralisPCRMATMLST (multilocus sequence typing)doghamster |
| spellingShingle | Ning Song Wenlong Zhang Yue Ding Dianjun Wu Zonghao Dai Li Xu Yongguo Cao Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China Frontiers in Veterinary Science Leptospira interrogans Serovar Australis PCR MAT MLST (multilocus sequence typing) dog hamster |
| title | Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China |
| title_full | Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China |
| title_fullStr | Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China |
| title_full_unstemmed | Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China |
| title_short | Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China |
| title_sort | preliminary characterization of dog derived pathogenic strains of leptospira interrogans serovar australis in nanchang of jiangxi province china |
| topic | Leptospira interrogans Serovar Australis PCR MAT MLST (multilocus sequence typing) dog hamster |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2020.607115/full |
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