Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection
Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1067725/full |
| _version_ | 1828067656258813952 |
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| author | Jicheng Han Jicheng Han Xiangyu Zhu Xiangyu Zhu Zihan Gao Zihan Gao Yan Xiao Yan Xiao Jinxin Zhang Jinxin Zhang Peng Wang Peng Wang Jinbo Fang Yiquan Li Yilong Zhu Yue Li Yue Li Ningyi Jin Ningyi Jin Huijun Lu Dazhuan Lin Wenshen Liu |
| author_facet | Jicheng Han Jicheng Han Xiangyu Zhu Xiangyu Zhu Zihan Gao Zihan Gao Yan Xiao Yan Xiao Jinxin Zhang Jinxin Zhang Peng Wang Peng Wang Jinbo Fang Yiquan Li Yilong Zhu Yue Li Yue Li Ningyi Jin Ningyi Jin Huijun Lu Dazhuan Lin Wenshen Liu |
| author_sort | Jicheng Han |
| collection | DOAJ |
| description | Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria lineage viruses has increased significantly during this period. Therefore, the prevention and treatment of the influenza B Victoria strain virus should continue to attract research attention. In this study, we found that Atractyloside A (AA), one of the effective components in Atractylodes lancea (Thunb.) DC shows potential antiviral properties. This study shows that AA not only possesses anti-influenza B virus infection effects in vivo and in vitro but also can regulate macrophage polarization to the M2 type, which can effectively attenuate the damage caused by influenza B virus infection. Therefore, Atractyloside A may be an effective natural drug against B/Victoria influenza infection. |
| first_indexed | 2024-04-10T23:48:59Z |
| format | Article |
| id | doaj.art-474724e5414442a49eb9fd4d5ff26385 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-10T23:48:59Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-474724e5414442a49eb9fd4d5ff263852023-01-10T20:26:03ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-01-011310.3389/fmicb.2022.10677251067725Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infectionJicheng Han0Jicheng Han1Xiangyu Zhu2Xiangyu Zhu3Zihan Gao4Zihan Gao5Yan Xiao6Yan Xiao7Jinxin Zhang8Jinxin Zhang9Peng Wang10Peng Wang11Jinbo Fang12Yiquan Li13Yilong Zhu14Yue Li15Yue Li16Ningyi Jin17Ningyi Jin18Huijun Lu19Dazhuan Lin20Wenshen Liu21Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, ChinaAcademician Workstation, Changchun University of Chinese Medicine, Changchun, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, ChinaAcademician Workstation, Changchun University of Chinese Medicine, Changchun, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, ChinaAcademician Workstation, Changchun University of Chinese Medicine, Changchun, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, ChinaAcademician Workstation, Changchun University of Chinese Medicine, Changchun, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaAcademician Workstation, Changchun University of Chinese Medicine, Changchun, ChinaAcademician Workstation, Changchun University of Chinese Medicine, Changchun, ChinaAcademician Workstation, Changchun University of Chinese Medicine, Changchun, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, ChinaAcademician Workstation, Changchun University of Chinese Medicine, Changchun, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, ChinaAcademician Workstation, Changchun University of Chinese Medicine, Changchun, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, ChinaCollege of Pharmaceuticals and Food, Changchun Medical College, Changchun, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, ChinaInfluenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria lineage viruses has increased significantly during this period. Therefore, the prevention and treatment of the influenza B Victoria strain virus should continue to attract research attention. In this study, we found that Atractyloside A (AA), one of the effective components in Atractylodes lancea (Thunb.) DC shows potential antiviral properties. This study shows that AA not only possesses anti-influenza B virus infection effects in vivo and in vitro but also can regulate macrophage polarization to the M2 type, which can effectively attenuate the damage caused by influenza B virus infection. Therefore, Atractyloside A may be an effective natural drug against B/Victoria influenza infection.https://www.frontiersin.org/articles/10.3389/fmicb.2022.1067725/fullAtractyloside Aantiviral drugsmacrophage polarizationinfluenza virusinfluenza B virus (IBV) |
| spellingShingle | Jicheng Han Jicheng Han Xiangyu Zhu Xiangyu Zhu Zihan Gao Zihan Gao Yan Xiao Yan Xiao Jinxin Zhang Jinxin Zhang Peng Wang Peng Wang Jinbo Fang Yiquan Li Yilong Zhu Yue Li Yue Li Ningyi Jin Ningyi Jin Huijun Lu Dazhuan Lin Wenshen Liu Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection Frontiers in Microbiology Atractyloside A antiviral drugs macrophage polarization influenza virus influenza B virus (IBV) |
| title | Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection |
| title_full | Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection |
| title_fullStr | Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection |
| title_full_unstemmed | Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection |
| title_short | Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection |
| title_sort | antiviral effects of atractyloside a on the influenza b virus victoria strain infection |
| topic | Atractyloside A antiviral drugs macrophage polarization influenza virus influenza B virus (IBV) |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1067725/full |
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