Compromised quality of life in adult patients who have received a radiation dose towards the basal part of the brain. A case-control study in long-term survivors from cancer in the head and neck region
<p>Abstract</p> <p>Background</p> <p>Adult patients with hypothalamic-pituitary disorders have compromised quality of life (QoL). Whether this is due to their endocrine consequences (hypopituitarism), their underlying hypothalamic-pituitary disorder or both is still und...
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| Format: | Article |
| Language: | English |
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BMC
2012-10-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.ro-journal.com/content/7/1/179 |
| _version_ | 1819115177096773632 |
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| author | Löfdahl Elisabet Berg Gertrud Johansson Karl-Axel Zachrisson Maria Malmgren Helge Mercke Claes Olsson Erik Wiren Lena Johannsson Gudmundur |
| author_facet | Löfdahl Elisabet Berg Gertrud Johansson Karl-Axel Zachrisson Maria Malmgren Helge Mercke Claes Olsson Erik Wiren Lena Johannsson Gudmundur |
| author_sort | Löfdahl Elisabet |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Adult patients with hypothalamic-pituitary disorders have compromised quality of life (QoL). Whether this is due to their endocrine consequences (hypopituitarism), their underlying hypothalamic-pituitary disorder or both is still under debate. The aim of this trial was to measure quality of life (QoL) in long-term cancer survivors who have received a radiation dose to the basal part of the brain and the pituitary.</p> <p>Methods</p> <p>Consecutive patients (n=101) treated for oropharyngeal or epipharyngeal cancer with radiotherapy followed free of cancer for a period of 4 to10 years were identified. Fifteen patients (median age 56 years) with no concomitant illness and no hypopituitarism after careful endocrine evaluation were included in a case-control study with matched healthy controls. Doses to the hypothalamic-pituitary region were calculated. QoL was assessed using the Symptom check list (SCL)-90, Nottingham Health Profile (NHP), and Psychological Well Being (PGWB) questionnaires. Level of physical activity was assessed using the Baecke questionnaire.</p> <p>Results</p> <p>The median accumulated dose was 1.9 Gy (1.5–2.2 Gy) to the hypothalamus and 2.4 Gy (1.8–3.3 Gy) to the pituitary gland in patients with oropharyngeal cancer and 6.0–9.3 Gy and 33.5–46.1 Gy, respectively in patients with epipharyngeal cancer (n=2). The patients showed significantly more anxiety and depressiveness, and lower vitality, than their matched controls.</p> <p>Conclusion</p> <p>In a group of long time survivors of head and neck cancer who hade received a low radiation dose to the hypothalamic-pituitary region and who had no endocrine consequences of disease or its treatment QoL was compromised as compared with well matched healthy controls.</p> |
| first_indexed | 2024-12-22T04:57:02Z |
| format | Article |
| id | doaj.art-4747a8bb28a545f4addc591e3dad58e8 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-22T04:57:02Z |
| publishDate | 2012-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-4747a8bb28a545f4addc591e3dad58e82022-12-21T18:38:20ZengBMCRadiation Oncology1748-717X2012-10-017117910.1186/1748-717X-7-179Compromised quality of life in adult patients who have received a radiation dose towards the basal part of the brain. A case-control study in long-term survivors from cancer in the head and neck regionLöfdahl ElisabetBerg GertrudJohansson Karl-AxelZachrisson MariaMalmgren HelgeMercke ClaesOlsson ErikWiren LenaJohannsson Gudmundur<p>Abstract</p> <p>Background</p> <p>Adult patients with hypothalamic-pituitary disorders have compromised quality of life (QoL). Whether this is due to their endocrine consequences (hypopituitarism), their underlying hypothalamic-pituitary disorder or both is still under debate. The aim of this trial was to measure quality of life (QoL) in long-term cancer survivors who have received a radiation dose to the basal part of the brain and the pituitary.</p> <p>Methods</p> <p>Consecutive patients (n=101) treated for oropharyngeal or epipharyngeal cancer with radiotherapy followed free of cancer for a period of 4 to10 years were identified. Fifteen patients (median age 56 years) with no concomitant illness and no hypopituitarism after careful endocrine evaluation were included in a case-control study with matched healthy controls. Doses to the hypothalamic-pituitary region were calculated. QoL was assessed using the Symptom check list (SCL)-90, Nottingham Health Profile (NHP), and Psychological Well Being (PGWB) questionnaires. Level of physical activity was assessed using the Baecke questionnaire.</p> <p>Results</p> <p>The median accumulated dose was 1.9 Gy (1.5–2.2 Gy) to the hypothalamus and 2.4 Gy (1.8–3.3 Gy) to the pituitary gland in patients with oropharyngeal cancer and 6.0–9.3 Gy and 33.5–46.1 Gy, respectively in patients with epipharyngeal cancer (n=2). The patients showed significantly more anxiety and depressiveness, and lower vitality, than their matched controls.</p> <p>Conclusion</p> <p>In a group of long time survivors of head and neck cancer who hade received a low radiation dose to the hypothalamic-pituitary region and who had no endocrine consequences of disease or its treatment QoL was compromised as compared with well matched healthy controls.</p>http://www.ro-journal.com/content/7/1/179Growth hormoneHead-and-neck cancerQuality of lifeCNSLow-dose-radiationLong-term survivors |
| spellingShingle | Löfdahl Elisabet Berg Gertrud Johansson Karl-Axel Zachrisson Maria Malmgren Helge Mercke Claes Olsson Erik Wiren Lena Johannsson Gudmundur Compromised quality of life in adult patients who have received a radiation dose towards the basal part of the brain. A case-control study in long-term survivors from cancer in the head and neck region Radiation Oncology Growth hormone Head-and-neck cancer Quality of life CNS Low-dose-radiation Long-term survivors |
| title | Compromised quality of life in adult patients who have received a radiation dose towards the basal part of the brain. A case-control study in long-term survivors from cancer in the head and neck region |
| title_full | Compromised quality of life in adult patients who have received a radiation dose towards the basal part of the brain. A case-control study in long-term survivors from cancer in the head and neck region |
| title_fullStr | Compromised quality of life in adult patients who have received a radiation dose towards the basal part of the brain. A case-control study in long-term survivors from cancer in the head and neck region |
| title_full_unstemmed | Compromised quality of life in adult patients who have received a radiation dose towards the basal part of the brain. A case-control study in long-term survivors from cancer in the head and neck region |
| title_short | Compromised quality of life in adult patients who have received a radiation dose towards the basal part of the brain. A case-control study in long-term survivors from cancer in the head and neck region |
| title_sort | compromised quality of life in adult patients who have received a radiation dose towards the basal part of the brain a case control study in long term survivors from cancer in the head and neck region |
| topic | Growth hormone Head-and-neck cancer Quality of life CNS Low-dose-radiation Long-term survivors |
| url | http://www.ro-journal.com/content/7/1/179 |
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