New Reassortant H5N8 Highly Pathogenic Avian Influenza Virus from Waterfowl in Southern China
New reassortant highly pathogenic H5N8 avian influenza viruses were isolated from waterfowl in Southern China. Blast analysis demonstrated that the PB2 gene in these viruses were most closely related to A/wild duck/Shangdong/628/2011 (H5N1), while their NP genes were both more closely related to A/w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-10-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01170/full |
| _version_ | 1811324244784578560 |
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| author | Yafen eSong Jin eCui Hui eSong Jiaqi eYe Zhishan eZhao Siyu eWu Chenggang eXu Peirong eJiao Ming eLiao |
| author_facet | Yafen eSong Jin eCui Hui eSong Jiaqi eYe Zhishan eZhao Siyu eWu Chenggang eXu Peirong eJiao Ming eLiao |
| author_sort | Yafen eSong |
| collection | DOAJ |
| description | New reassortant highly pathogenic H5N8 avian influenza viruses were isolated from waterfowl in Southern China. Blast analysis demonstrated that the PB2 gene in these viruses were most closely related to A/wild duck/Shangdong/628/2011 (H5N1), while their NP genes were both more closely related to A/wild duck/Shandong/1/2011 (H5N1) and A/duck/Jiangsu/k1203/2010 (H5N8). However, the HA, NA, PB1, PA, M, and NS genes had the highest homology with A/duck/Jiangsu/k1203/2010 (H5N8). Phylogenetic analysis revealed that their HA genes belonged to the same GsGd H5 clade 2.3.4.4 detected in China in 2010. Therefore, we supposed that these H5N8 viruses might be novel reassortant viruses that have a H5N8 backbone while acquiring PB2 and NP genes from H5N1 viruses. This study is useful for better understanding the genetic and antigenic evolution of H5 avian influenza viruses in Southern China. |
| first_indexed | 2024-04-13T14:10:55Z |
| format | Article |
| id | doaj.art-47481ba9242149ada259935249a96964 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T14:10:55Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-47481ba9242149ada259935249a969642022-12-22T02:43:48ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-10-01610.3389/fmicb.2015.01170159795New Reassortant H5N8 Highly Pathogenic Avian Influenza Virus from Waterfowl in Southern ChinaYafen eSong0Jin eCui1Hui eSong2Jiaqi eYe3Zhishan eZhao4Siyu eWu5Chenggang eXu6Peirong eJiao7Ming eLiao8College of Veterinary Medicine, South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityCollege of Life Science,South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityNew reassortant highly pathogenic H5N8 avian influenza viruses were isolated from waterfowl in Southern China. Blast analysis demonstrated that the PB2 gene in these viruses were most closely related to A/wild duck/Shangdong/628/2011 (H5N1), while their NP genes were both more closely related to A/wild duck/Shandong/1/2011 (H5N1) and A/duck/Jiangsu/k1203/2010 (H5N8). However, the HA, NA, PB1, PA, M, and NS genes had the highest homology with A/duck/Jiangsu/k1203/2010 (H5N8). Phylogenetic analysis revealed that their HA genes belonged to the same GsGd H5 clade 2.3.4.4 detected in China in 2010. Therefore, we supposed that these H5N8 viruses might be novel reassortant viruses that have a H5N8 backbone while acquiring PB2 and NP genes from H5N1 viruses. This study is useful for better understanding the genetic and antigenic evolution of H5 avian influenza viruses in Southern China.http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01170/fullSouthern ChinawaterfowlReassortantHighly pathogenic avian influenza virusH5N8 |
| spellingShingle | Yafen eSong Jin eCui Hui eSong Jiaqi eYe Zhishan eZhao Siyu eWu Chenggang eXu Peirong eJiao Ming eLiao New Reassortant H5N8 Highly Pathogenic Avian Influenza Virus from Waterfowl in Southern China Frontiers in Microbiology Southern China waterfowl Reassortant Highly pathogenic avian influenza virus H5N8 |
| title | New Reassortant H5N8 Highly Pathogenic Avian Influenza Virus from Waterfowl in Southern China |
| title_full | New Reassortant H5N8 Highly Pathogenic Avian Influenza Virus from Waterfowl in Southern China |
| title_fullStr | New Reassortant H5N8 Highly Pathogenic Avian Influenza Virus from Waterfowl in Southern China |
| title_full_unstemmed | New Reassortant H5N8 Highly Pathogenic Avian Influenza Virus from Waterfowl in Southern China |
| title_short | New Reassortant H5N8 Highly Pathogenic Avian Influenza Virus from Waterfowl in Southern China |
| title_sort | new reassortant h5n8 highly pathogenic avian influenza virus from waterfowl in southern china |
| topic | Southern China waterfowl Reassortant Highly pathogenic avian influenza virus H5N8 |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01170/full |
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