Synchronous solid pseudopapillary neoplasm and invasive ductal carcinoma of the pancreas: a case report
Abstract Background Solid pseudopapillary neoplasm (SPN) of the pancreas is an extremely rare neoplasm with a favorable prognosis. On the other hand, pancreatic invasive ductal carcinoma (IDC) is known to be an aggressive malignancy. To the best of our knowledge, there is no report of SPN combined w...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-08-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-020-00969-9 |
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| author | Chikanori Tsutsumi Toshiya Abe Yusuke Sawatsubashi Sadafumi Tamiya Daisuke Kakihara Kazuyoshi Nishihara Toru Nakano |
| author_facet | Chikanori Tsutsumi Toshiya Abe Yusuke Sawatsubashi Sadafumi Tamiya Daisuke Kakihara Kazuyoshi Nishihara Toru Nakano |
| author_sort | Chikanori Tsutsumi |
| collection | DOAJ |
| description | Abstract Background Solid pseudopapillary neoplasm (SPN) of the pancreas is an extremely rare neoplasm with a favorable prognosis. On the other hand, pancreatic invasive ductal carcinoma (IDC) is known to be an aggressive malignancy. To the best of our knowledge, there is no report of SPN combined with IDC of the pancreas. Case presentation A 66-year-old woman presented with abnormal genital bleeding and was diagnosed with inoperable cervical cancer. During computed tomography for cancer staging, the patient was incidentally diagnosed with pancreatic cancer. After radiation therapy for the cervical cancer, distal pancreatectomy with D2 lymph node dissection was performed. A postoperative pathological examination revealed SPN with ossification and well-differentiated IDC in the pancreatic body. On immunohistochemical staining, SPN tumor cells showed positive β-catenin and CD10 staining, whereas IDC cells were negative for both. The tumor boundaries were clear. Accordingly, the final pathological diagnosis was synchronous SPN and IDC of the pancreas. Moreover, pathological findings such as the ossification and small number of SPN cells suggested that SPN may have existed long before IDC initiation. Conclusions Here, we report the first case of SPN combined with IDC of the pancreas. They may occur independently, and the long-term presence of SPN may lead to the development of IDC. |
| first_indexed | 2024-12-13T02:51:22Z |
| format | Article |
| id | doaj.art-474b77271b254dd2a57ca620cb111b5f |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-13T02:51:22Z |
| publishDate | 2020-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-474b77271b254dd2a57ca620cb111b5f2022-12-22T00:02:04ZengSpringerOpenSurgical Case Reports2198-77932020-08-01611710.1186/s40792-020-00969-9Synchronous solid pseudopapillary neoplasm and invasive ductal carcinoma of the pancreas: a case reportChikanori Tsutsumi0Toshiya Abe1Yusuke Sawatsubashi2Sadafumi Tamiya3Daisuke Kakihara4Kazuyoshi Nishihara5Toru Nakano6Department of Surgery, Kitakyushu Municipal Medical CenterDepartment of Surgery, Kitakyushu Municipal Medical CenterDepartment of Surgery, Kitakyushu Municipal Medical CenterDepartment of Pathology, Kitakyushu Municipal Medical CenterDepartment of Radiology, Kitakyushu Municipal Medical CenterDepartment of Surgery, Kitakyushu Municipal Medical CenterDepartment of Surgery, Kitakyushu Municipal Medical CenterAbstract Background Solid pseudopapillary neoplasm (SPN) of the pancreas is an extremely rare neoplasm with a favorable prognosis. On the other hand, pancreatic invasive ductal carcinoma (IDC) is known to be an aggressive malignancy. To the best of our knowledge, there is no report of SPN combined with IDC of the pancreas. Case presentation A 66-year-old woman presented with abnormal genital bleeding and was diagnosed with inoperable cervical cancer. During computed tomography for cancer staging, the patient was incidentally diagnosed with pancreatic cancer. After radiation therapy for the cervical cancer, distal pancreatectomy with D2 lymph node dissection was performed. A postoperative pathological examination revealed SPN with ossification and well-differentiated IDC in the pancreatic body. On immunohistochemical staining, SPN tumor cells showed positive β-catenin and CD10 staining, whereas IDC cells were negative for both. The tumor boundaries were clear. Accordingly, the final pathological diagnosis was synchronous SPN and IDC of the pancreas. Moreover, pathological findings such as the ossification and small number of SPN cells suggested that SPN may have existed long before IDC initiation. Conclusions Here, we report the first case of SPN combined with IDC of the pancreas. They may occur independently, and the long-term presence of SPN may lead to the development of IDC.http://link.springer.com/article/10.1186/s40792-020-00969-9Solid pseudopapillary neoplasmInvasive ductal carcinomaPancreatic neoplasmSynchronousPancreatitis |
| spellingShingle | Chikanori Tsutsumi Toshiya Abe Yusuke Sawatsubashi Sadafumi Tamiya Daisuke Kakihara Kazuyoshi Nishihara Toru Nakano Synchronous solid pseudopapillary neoplasm and invasive ductal carcinoma of the pancreas: a case report Surgical Case Reports Solid pseudopapillary neoplasm Invasive ductal carcinoma Pancreatic neoplasm Synchronous Pancreatitis |
| title | Synchronous solid pseudopapillary neoplasm and invasive ductal carcinoma of the pancreas: a case report |
| title_full | Synchronous solid pseudopapillary neoplasm and invasive ductal carcinoma of the pancreas: a case report |
| title_fullStr | Synchronous solid pseudopapillary neoplasm and invasive ductal carcinoma of the pancreas: a case report |
| title_full_unstemmed | Synchronous solid pseudopapillary neoplasm and invasive ductal carcinoma of the pancreas: a case report |
| title_short | Synchronous solid pseudopapillary neoplasm and invasive ductal carcinoma of the pancreas: a case report |
| title_sort | synchronous solid pseudopapillary neoplasm and invasive ductal carcinoma of the pancreas a case report |
| topic | Solid pseudopapillary neoplasm Invasive ductal carcinoma Pancreatic neoplasm Synchronous Pancreatitis |
| url | http://link.springer.com/article/10.1186/s40792-020-00969-9 |
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