Sex bias in celiac disease: XWAS and monocyte eQTLs in women identify TMEM187 as a functional candidate gene

Sex bias in celiac disease: XWAS and monocyte eQTLs in women identify TMEM187 as a functional candidate gene

Abstract Background Celiac disease (CeD) is an immune-mediated disorder that develops in genetically predisposed individuals upon gluten consumption. HLA risk alleles explain 40% of the genetic component of CeD, so there have been continuing efforts to uncover non-HLA loci that can explain the remai...

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Bibliographic Details
Main Authors: Alba Hernangomez-Laderas, Ariadna Cilleros-Portet, Silvia Martínez Velasco, Sergi Marí, María Legarda, Bárbara Paola González-García, Carlos Tutau, Iraia García-Santisteban, Iñaki Irastorza, Nora Fernandez-Jimenez, Jose Ramon Bilbao
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Biology of Sex Differences
Subjects:
Celiac disease
XWAS
Mendelian randomization
TMEM187
Monocytes
eQTLs
Online Access:https://doi.org/10.1186/s13293-023-00572-1

Internet

https://doi.org/10.1186/s13293-023-00572-1

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