Optimization and Validation of a Novel Three-Dimensional Co-Culture System in Decellularized Human Liver Scaffold for the Study of Liver Fibrosis and Cancer

Optimization and Validation of a Novel Three-Dimensional Co-Culture System in Decellularized Human Liver Scaffold for the Study of Liver Fibrosis and Cancer

The introduction of new preclinical models for in vitro drug discovery and testing based on 3D tissue-specific extracellular matrix (ECM) is very much awaited. This study was aimed at developing and validating a co-culture model using decellularized human liver 3D ECM scaffolds as a platform for ant...

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Bibliographic Details
Main Authors: Kessarin Thanapirom, Elisabetta Caon, Margarita Papatheodoridi, Luca Frenguelli, Walid Al-Akkad, Zhang Zhenzhen, Maria Giovanna Vilia, Massimo Pinzani, Giuseppe Mazza, Krista Rombouts
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
decellularized liver scaffolds
drug screening
liver fibrosis
liver cancer
sorafenib
regorafenib
Online Access:https://www.mdpi.com/2072-6694/13/19/4936

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