Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesity
Background & Objective: Genome-wide association studies (GWAS) has identified that FTO gene polymorphisms was associated with the risk of type 2 diabetes and obesity. However, the findings in subsequent studies were inconsistent in various populations. This study aimed to investigate the associa...
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| Format: | Article |
| Language: | fas |
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Fasa University of Medical Sciences
2016-04-01
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| Series: | Journal of Fasa University of Medical Sciences |
| Subjects: | |
| Online Access: | http://journal.fums.ac.ir/browse.php?a_code=A-10-891-1&slc_lang=en&sid=1 |
| _version_ | 1819266843632730112 |
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| author | mohammad bakhshi ganje mohamad hassan shekhha ehsan farashahi morteza mohammadzade |
| author_facet | mohammad bakhshi ganje mohamad hassan shekhha ehsan farashahi morteza mohammadzade |
| author_sort | mohammad bakhshi ganje |
| collection | DOAJ |
| description | Background & Objective: Genome-wide association studies (GWAS) has identified that FTO gene polymorphisms was associated with the risk of type 2 diabetes and obesity. However, the findings in subsequent studies were inconsistent in various populations. This study aimed to investigate the association of FTO rs16953002 with type 2 diabetes and obesity in Yazd, Iran.
Methods & Materials: Unrelated study subject controls (n=200) and type 2 diabetes cases (T2DM) (n=200), were randomly selected from Yazd, Iran. Genotyping was done by the polymerase chain reaction-restriction fragment length polymorphism method. Age and gender, smoking, weight and body mass index (BMI) were analyzed using the analysis of χ2 test.
Results: The rs16953002 A/G polymorphism of the FTO gene showed significant association with T2DM and obesity. The AG, GG genotypes were significantly higher in T2DM and obese subjects compared to the group subjects.
Conclusions: The result of the present study indicate that the genetic variant in FTO may contribute to T2DM and obesity risk in Yazd population. |
| first_indexed | 2024-12-23T21:07:43Z |
| format | Article |
| id | doaj.art-474e542ae090435681c7f83ba4146a33 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2228-7329 |
| language | fas |
| last_indexed | 2024-12-23T21:07:43Z |
| publishDate | 2016-04-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Fasa University of Medical Sciences |
| spelling | doaj.art-474e542ae090435681c7f83ba4146a332022-12-21T17:31:10ZfasFasa University of Medical SciencesJournal of Fasa University of Medical Sciences2228-51052228-73292016-04-01612734Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesitymohammad bakhshi ganje0mohamad hassan shekhha1ehsan farashahi2morteza mohammadzade3 Genetics Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Yazd Clinical and Research Center for Infertility, Shahid Sadoughi University of Medical Science, Yazd, Iran Yazd Clinical and Research Center for Infertility, Shahid Sadoughi University of Medical Science, Yazd, Iran Genetics Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Background & Objective: Genome-wide association studies (GWAS) has identified that FTO gene polymorphisms was associated with the risk of type 2 diabetes and obesity. However, the findings in subsequent studies were inconsistent in various populations. This study aimed to investigate the association of FTO rs16953002 with type 2 diabetes and obesity in Yazd, Iran. Methods & Materials: Unrelated study subject controls (n=200) and type 2 diabetes cases (T2DM) (n=200), were randomly selected from Yazd, Iran. Genotyping was done by the polymerase chain reaction-restriction fragment length polymorphism method. Age and gender, smoking, weight and body mass index (BMI) were analyzed using the analysis of χ2 test. Results: The rs16953002 A/G polymorphism of the FTO gene showed significant association with T2DM and obesity. The AG, GG genotypes were significantly higher in T2DM and obese subjects compared to the group subjects. Conclusions: The result of the present study indicate that the genetic variant in FTO may contribute to T2DM and obesity risk in Yazd population.http://journal.fums.ac.ir/browse.php?a_code=A-10-891-1&slc_lang=en&sid=1FTO gene Type 2 diabetes Obesity Polymorphism |
| spellingShingle | mohammad bakhshi ganje mohamad hassan shekhha ehsan farashahi morteza mohammadzade Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesity Journal of Fasa University of Medical Sciences FTO gene Type 2 diabetes Obesity Polymorphism |
| title | Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesity |
| title_full | Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesity |
| title_fullStr | Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesity |
| title_full_unstemmed | Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesity |
| title_short | Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesity |
| title_sort | association of rs16953002 fto gene polymorphism with type 2 diabetes and obesity |
| topic | FTO gene Type 2 diabetes Obesity Polymorphism |
| url | http://journal.fums.ac.ir/browse.php?a_code=A-10-891-1&slc_lang=en&sid=1 |
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