The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy

The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy

The bromodomain and extraterminal (BET) family member BRD4 is pivotal in the pathogenesis of cardiac hypertrophy. BRD4 induces hypertrophic gene expression by binding to the acetylated chromatin, facilitating the phosphorylation of RNA polymerases II (Pol II) and leading to transcription elongation....

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Bibliographic Details
Main Authors: Zhenzhen Li, Zhen Guo, Rui Lan, Sidong Cai, Zhirong Lin, Jingyan Li, Junjian Wang, Zhuoming Li, Peiqing Liu
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
BRD4
PARP1
PARylation
Isoproterenol
Cardiac hypertrophy
RNA Pol II
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520308455

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