New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice
A new biological model of moderate inhibition of tumor growth and metastases with prolonged leukopenia on C57BI/6 mice with the Lewis Lung Carcinoma was designed. The model was created by the injection of cyclophosphamide (dose 83.3 mg/kg) on 6th, 12th, 18th days after tumor cells transplantation on...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2016-09-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/292 |
| _version_ | 1797237401292111872 |
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| author | O. Y. Rybalkina N. N. Ermakova T. G. Razina E. G. Skurikhin E. P. Zueva |
| author_facet | O. Y. Rybalkina N. N. Ermakova T. G. Razina E. G. Skurikhin E. P. Zueva |
| author_sort | O. Y. Rybalkina |
| collection | DOAJ |
| description | A new biological model of moderate inhibition of tumor growth and metastases with prolonged leukopenia on C57BI/6 mice with the Lewis Lung Carcinoma was designed. The model was created by the injection of cyclophosphamide (dose 83.3 mg/kg) on 6th, 12th, 18th days after tumor cells transplantation on animals. Experiment showed that 3-fold cyclophosphamide use leads to growth of primary tumor and metastases inhibition. Tumor growth inhibition was 34 % on 21st day after cyclophosphamide inject. The number of metastases decreased by 4.7 times (p < 0,01). Metastatic area reduced. Metastasis frequency made 100 %. In addition, the course of cyclophosphamide application caused inhibition of granulocytic and lymphoid hematopoiesis. The reducing the number of segmented neutrophils and lymphocytes was showed on the 3rd day after 1, 2 and 3 injections of cyclophosphamide. The model can be used to study the efficacy of drugs in tumor therapy and in correction of such toxic manifestation of chemotherapy as leukopenia. |
| first_indexed | 2024-03-08T12:18:51Z |
| format | Article |
| id | doaj.art-47512e2174f547a4941b5e2961d55fea |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:19:10Z |
| publishDate | 2016-09-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-47512e2174f547a4941b5e2961d55fea2024-03-28T07:49:16ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962016-09-011512112510.12737/23406292New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in miceO. Y. Rybalkina0N. N. Ermakova1T. G. Razina2E. G. Skurikhin3E. P. Zueva4Goldberg Research Institute of Pharmacology and Regenerative Medicine; National Research Tomsk State UniversityGoldberg Research Institute of Pharmacology and Regenerative MedicineGoldberg Research Institute of Pharmacology and Regenerative MedicineGoldberg Research Institute of Pharmacology and Regenerative MedicineGoldberg Research Institute of Pharmacology and Regenerative MedicineA new biological model of moderate inhibition of tumor growth and metastases with prolonged leukopenia on C57BI/6 mice with the Lewis Lung Carcinoma was designed. The model was created by the injection of cyclophosphamide (dose 83.3 mg/kg) on 6th, 12th, 18th days after tumor cells transplantation on animals. Experiment showed that 3-fold cyclophosphamide use leads to growth of primary tumor and metastases inhibition. Tumor growth inhibition was 34 % on 21st day after cyclophosphamide inject. The number of metastases decreased by 4.7 times (p < 0,01). Metastatic area reduced. Metastasis frequency made 100 %. In addition, the course of cyclophosphamide application caused inhibition of granulocytic and lymphoid hematopoiesis. The reducing the number of segmented neutrophils and lymphocytes was showed on the 3rd day after 1, 2 and 3 injections of cyclophosphamide. The model can be used to study the efficacy of drugs in tumor therapy and in correction of such toxic manifestation of chemotherapy as leukopenia.https://www.actabiomedica.ru/jour/article/view/292experimental modelcyclophosphamidelewis lung carcinomaleukopenia |
| spellingShingle | O. Y. Rybalkina N. N. Ermakova T. G. Razina E. G. Skurikhin E. P. Zueva New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice Acta Biomedica Scientifica experimental model cyclophosphamide lewis lung carcinoma leukopenia |
| title | New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice |
| title_full | New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice |
| title_fullStr | New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice |
| title_full_unstemmed | New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice |
| title_short | New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice |
| title_sort | new biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice |
| topic | experimental model cyclophosphamide lewis lung carcinoma leukopenia |
| url | https://www.actabiomedica.ru/jour/article/view/292 |
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