Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group.

Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group.

The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets via promoter-based GGAA-microsatellite response elements. These microsatellites are highly polymorphic in humans, and preliminary evidence...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Michael J Monument, Kirsten M Johnson, Elizabeth McIlvaine, Lisa Abegglen, W Scott Watkins, Lynn B Jorde, Richard B Womer, Natalie Beeler, Laura Monovich, Elizabeth R Lawlor, Julia A Bridge, Joshua D Schiffman, Mark D Krailo, R Lor Randall, Stephen L Lessnick
Format: Artikel
Sprache:English
Veröffentlicht: Public Library of Science (PLoS) 2014-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC4122435?pdf=render

Online

http://europepmc.org/articles/PMC4122435?pdf=render

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