Arterial stiffness and the non-dipping pattern in type 1 diabetes males with and without erectile dysfunction
Abstract Arterial stiffness (AS) and non-dipping pattern are early predictors of cardiovascular diseases but are not used in clinical practice. We aimed to assess if AS and the non-dipping pattern are more prevalent in the erectile dysfunction (ED) group than in the non-ED group among subjects with...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33315-8 |
| _version_ | 1827952719298560000 |
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| author | Michał Kulecki Dariusz Naskret Mikolaj Kaminski Dominika Kasprzak Pawel Lachowski Daria Klause Maria Kozlowska Justyna Flotynska Aleksandra Uruska Dorota Zozulinska-Ziolkiewicz |
| author_facet | Michał Kulecki Dariusz Naskret Mikolaj Kaminski Dominika Kasprzak Pawel Lachowski Daria Klause Maria Kozlowska Justyna Flotynska Aleksandra Uruska Dorota Zozulinska-Ziolkiewicz |
| author_sort | Michał Kulecki |
| collection | DOAJ |
| description | Abstract Arterial stiffness (AS) and non-dipping pattern are early predictors of cardiovascular diseases but are not used in clinical practice. We aimed to assess if AS and the non-dipping pattern are more prevalent in the erectile dysfunction (ED) group than in the non-ED group among subjects with type 1 diabetes (T1DM). The study group consisted of adults with T1DM. Aortic pulse wave velocity (PWV Ao)—a marker of increased AS, central systolic blood pressure, and heart rate (HR) were measured with a brachial oscillometric device (Arteriograph 24). Erectile dysfunction (ED) was assessed by the International Index of Erectile Function-5. A comparison between the groups with and without ED was performed. Of 34 investigated men with T1DM, 12 (35.3%) suffered from ED. The group with ED had higher mean 24 h HR (77.7 [73.7–86.5] vs 69.9 [64.0–76.8]/min; p = 0.04, nighttime PWV Ao (8.1 [6.8–8.5] vs 6.8 [6.1–7.5] m/s; p = 0.015) and prevalence of non-dipping SBP Ao pattern (11 [91.7] vs 12 [54.5]%; p = 0.027) than individuals without ED. The presence of ED detected a central non-dipping pattern with a sensitivity of 47.8% and a specificity of 90.9%. The central non-dipping pattern was more prevalent and the nighttime PWV was higher in T1DM subjects with ED than in those without ED. |
| first_indexed | 2024-04-09T14:02:02Z |
| format | Article |
| id | doaj.art-475217ddb9d0420ca7af2ee32da056ed |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T14:02:02Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-475217ddb9d0420ca7af2ee32da056ed2023-05-07T11:12:40ZengNature PortfolioScientific Reports2045-23222023-05-011311910.1038/s41598-023-33315-8Arterial stiffness and the non-dipping pattern in type 1 diabetes males with and without erectile dysfunctionMichał Kulecki0Dariusz Naskret1Mikolaj Kaminski2Dominika Kasprzak3Pawel Lachowski4Daria Klause5Maria Kozlowska6Justyna Flotynska7Aleksandra Uruska8Dorota Zozulinska-Ziolkiewicz9Department of Internal Medicine and Diabetology, Poznan University of Medical SciencesDepartment of Internal Medicine and Diabetology, Poznan University of Medical SciencesDepartment of Internal Medicine and Diabetology, Poznan University of Medical SciencesDepartment of Internal Medicine and Diabetology, Poznan University of Medical SciencesDepartment of Internal Medicine and Diabetology, Poznan University of Medical SciencesDepartment of Internal Medicine and Diabetology, Poznan University of Medical SciencesDepartment of Internal Medicine and Diabetology, Poznan University of Medical SciencesDepartment of Internal Medicine and Diabetology, Poznan University of Medical SciencesDepartment of Internal Medicine and Diabetology, Poznan University of Medical SciencesDepartment of Internal Medicine and Diabetology, Poznan University of Medical SciencesAbstract Arterial stiffness (AS) and non-dipping pattern are early predictors of cardiovascular diseases but are not used in clinical practice. We aimed to assess if AS and the non-dipping pattern are more prevalent in the erectile dysfunction (ED) group than in the non-ED group among subjects with type 1 diabetes (T1DM). The study group consisted of adults with T1DM. Aortic pulse wave velocity (PWV Ao)—a marker of increased AS, central systolic blood pressure, and heart rate (HR) were measured with a brachial oscillometric device (Arteriograph 24). Erectile dysfunction (ED) was assessed by the International Index of Erectile Function-5. A comparison between the groups with and without ED was performed. Of 34 investigated men with T1DM, 12 (35.3%) suffered from ED. The group with ED had higher mean 24 h HR (77.7 [73.7–86.5] vs 69.9 [64.0–76.8]/min; p = 0.04, nighttime PWV Ao (8.1 [6.8–8.5] vs 6.8 [6.1–7.5] m/s; p = 0.015) and prevalence of non-dipping SBP Ao pattern (11 [91.7] vs 12 [54.5]%; p = 0.027) than individuals without ED. The presence of ED detected a central non-dipping pattern with a sensitivity of 47.8% and a specificity of 90.9%. The central non-dipping pattern was more prevalent and the nighttime PWV was higher in T1DM subjects with ED than in those without ED.https://doi.org/10.1038/s41598-023-33315-8 |
| spellingShingle | Michał Kulecki Dariusz Naskret Mikolaj Kaminski Dominika Kasprzak Pawel Lachowski Daria Klause Maria Kozlowska Justyna Flotynska Aleksandra Uruska Dorota Zozulinska-Ziolkiewicz Arterial stiffness and the non-dipping pattern in type 1 diabetes males with and without erectile dysfunction Scientific Reports |
| title | Arterial stiffness and the non-dipping pattern in type 1 diabetes males with and without erectile dysfunction |
| title_full | Arterial stiffness and the non-dipping pattern in type 1 diabetes males with and without erectile dysfunction |
| title_fullStr | Arterial stiffness and the non-dipping pattern in type 1 diabetes males with and without erectile dysfunction |
| title_full_unstemmed | Arterial stiffness and the non-dipping pattern in type 1 diabetes males with and without erectile dysfunction |
| title_short | Arterial stiffness and the non-dipping pattern in type 1 diabetes males with and without erectile dysfunction |
| title_sort | arterial stiffness and the non dipping pattern in type 1 diabetes males with and without erectile dysfunction |
| url | https://doi.org/10.1038/s41598-023-33315-8 |
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