The impact of high circulating anti-müllerian hormone on endometrial thickness and outcome of assisted reproductive technology in women with polycystic ovarian syndrome: A cohort study
Background: Elevated circulating anti-Müllerian hormone (AMH) in women with the polycystic ovarian syndrome (PCOS) has been found to have a detrimental effect on endometrial function. This may adversely affect the outcome of in vitro fertilisation (IVF) in PCOS women. Aims: To investigate the impact...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2022;volume=15;issue=4;spage=370;epage=376;aulast=Mohamed |
| _version_ | 1797954853534695424 |
|---|---|
| author | Ahmed Aboelfadle Mohamed Tarek K Al-Hussaini Reda S Hussein Karim S Abdallah Saad A Amer |
| author_facet | Ahmed Aboelfadle Mohamed Tarek K Al-Hussaini Reda S Hussein Karim S Abdallah Saad A Amer |
| author_sort | Ahmed Aboelfadle Mohamed |
| collection | DOAJ |
| description | Background: Elevated circulating anti-Müllerian hormone (AMH) in women with the polycystic ovarian syndrome (PCOS) has been found to have a detrimental effect on endometrial function. This may adversely affect the outcome of in vitro fertilisation (IVF) in PCOS women. Aims: To investigate the impact of high serum AMH concentrations on endometrial thickness (ET) and the outcome of IVF in women with PCOS. Settings and Design: This retrospective cohort study included all PCOS women who underwent fresh IVF\intracytoplasmic sperm injection cycles between January 2016 and December 2021 in one major IVF centre. Materials and Methods: PCOS diagnosis was based on Rotterdam criteria, and participants were identified from centre database. All women received antagonist protocol. Primary outcomes were trigger-day ET and live birth rate (LBR). Circulating AMH was correlated with ET and ovarian response. Statistical Analysis Used: AMH levels were compared between women with and without live birth. ET and LBRs were compared between women with AMH <7.0 ng/ml versus those with AMH ≥7.0 ng/ml. Results: The study included 102 PCOS women, of which six were excluded due to poor response (n = 4), hyperresponse (n = 1) or fertilisation failure (n = 1). Of the remaining 96 women, 42 (43.8%) achieved a live birth. There was no statistically significant (P > 0.05) correlation between AMH and ET. Mean ± standard deviation AMH concentration was not significantly (P > 0.05) different between women with live birth (6.5 ± 3.4 ng/ml) and those without (6.5 ± 2.4 ng/ml). High AMH positively correlated with the number of oocytes retrieved, metaphase II oocytes and embryos (P = 0.003, 0.006 and 0.006, respectively). There was no statistically significant (P > 0.05) difference in ET or LBR between women with AMH <7.0 ng/ml (n = 72; ET, 10.7 ± 1.8 mm; LBR, 45.8% [33/72] versus those with AMH ≥7.0 ng/ml (n = 24; ET, 10.8 ± 1.7 mm; LBR, 37.5% [9/24]). Conclusions: High circulating AMH in PCOS women does not seem to negatively affect ET or LBRs during assisted reproductive technology. |
| first_indexed | 2024-04-10T23:23:57Z |
| format | Article |
| id | doaj.art-47526bfce2ad46ee88e8b935021764ed |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-04-10T23:23:57Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-47526bfce2ad46ee88e8b935021764ed2023-01-12T12:42:37ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662022-01-0115437037610.4103/jhrs.jhrs_112_22The impact of high circulating anti-müllerian hormone on endometrial thickness and outcome of assisted reproductive technology in women with polycystic ovarian syndrome: A cohort studyAhmed Aboelfadle MohamedTarek K Al-HussainiReda S HusseinKarim S AbdallahSaad A AmerBackground: Elevated circulating anti-Müllerian hormone (AMH) in women with the polycystic ovarian syndrome (PCOS) has been found to have a detrimental effect on endometrial function. This may adversely affect the outcome of in vitro fertilisation (IVF) in PCOS women. Aims: To investigate the impact of high serum AMH concentrations on endometrial thickness (ET) and the outcome of IVF in women with PCOS. Settings and Design: This retrospective cohort study included all PCOS women who underwent fresh IVF\intracytoplasmic sperm injection cycles between January 2016 and December 2021 in one major IVF centre. Materials and Methods: PCOS diagnosis was based on Rotterdam criteria, and participants were identified from centre database. All women received antagonist protocol. Primary outcomes were trigger-day ET and live birth rate (LBR). Circulating AMH was correlated with ET and ovarian response. Statistical Analysis Used: AMH levels were compared between women with and without live birth. ET and LBRs were compared between women with AMH <7.0 ng/ml versus those with AMH ≥7.0 ng/ml. Results: The study included 102 PCOS women, of which six were excluded due to poor response (n = 4), hyperresponse (n = 1) or fertilisation failure (n = 1). Of the remaining 96 women, 42 (43.8%) achieved a live birth. There was no statistically significant (P > 0.05) correlation between AMH and ET. Mean ± standard deviation AMH concentration was not significantly (P > 0.05) different between women with live birth (6.5 ± 3.4 ng/ml) and those without (6.5 ± 2.4 ng/ml). High AMH positively correlated with the number of oocytes retrieved, metaphase II oocytes and embryos (P = 0.003, 0.006 and 0.006, respectively). There was no statistically significant (P > 0.05) difference in ET or LBR between women with AMH <7.0 ng/ml (n = 72; ET, 10.7 ± 1.8 mm; LBR, 45.8% [33/72] versus those with AMH ≥7.0 ng/ml (n = 24; ET, 10.8 ± 1.7 mm; LBR, 37.5% [9/24]). Conclusions: High circulating AMH in PCOS women does not seem to negatively affect ET or LBRs during assisted reproductive technology.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2022;volume=15;issue=4;spage=370;epage=376;aulast=Mohamedanti-müllerian hormoneassisted reproductionendometrial thicknesspolycystic ovarian syndrome |
| spellingShingle | Ahmed Aboelfadle Mohamed Tarek K Al-Hussaini Reda S Hussein Karim S Abdallah Saad A Amer The impact of high circulating anti-müllerian hormone on endometrial thickness and outcome of assisted reproductive technology in women with polycystic ovarian syndrome: A cohort study Journal of Human Reproductive Sciences anti-müllerian hormone assisted reproduction endometrial thickness polycystic ovarian syndrome |
| title | The impact of high circulating anti-müllerian hormone on endometrial thickness and outcome of assisted reproductive technology in women with polycystic ovarian syndrome: A cohort study |
| title_full | The impact of high circulating anti-müllerian hormone on endometrial thickness and outcome of assisted reproductive technology in women with polycystic ovarian syndrome: A cohort study |
| title_fullStr | The impact of high circulating anti-müllerian hormone on endometrial thickness and outcome of assisted reproductive technology in women with polycystic ovarian syndrome: A cohort study |
| title_full_unstemmed | The impact of high circulating anti-müllerian hormone on endometrial thickness and outcome of assisted reproductive technology in women with polycystic ovarian syndrome: A cohort study |
| title_short | The impact of high circulating anti-müllerian hormone on endometrial thickness and outcome of assisted reproductive technology in women with polycystic ovarian syndrome: A cohort study |
| title_sort | impact of high circulating anti mullerian hormone on endometrial thickness and outcome of assisted reproductive technology in women with polycystic ovarian syndrome a cohort study |
| topic | anti-müllerian hormone assisted reproduction endometrial thickness polycystic ovarian syndrome |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2022;volume=15;issue=4;spage=370;epage=376;aulast=Mohamed |
| work_keys_str_mv | AT ahmedaboelfadlemohamed theimpactofhighcirculatingantimullerianhormoneonendometrialthicknessandoutcomeofassistedreproductivetechnologyinwomenwithpolycysticovariansyndromeacohortstudy AT tarekkalhussaini theimpactofhighcirculatingantimullerianhormoneonendometrialthicknessandoutcomeofassistedreproductivetechnologyinwomenwithpolycysticovariansyndromeacohortstudy AT redashussein theimpactofhighcirculatingantimullerianhormoneonendometrialthicknessandoutcomeofassistedreproductivetechnologyinwomenwithpolycysticovariansyndromeacohortstudy AT karimsabdallah theimpactofhighcirculatingantimullerianhormoneonendometrialthicknessandoutcomeofassistedreproductivetechnologyinwomenwithpolycysticovariansyndromeacohortstudy AT saadaamer theimpactofhighcirculatingantimullerianhormoneonendometrialthicknessandoutcomeofassistedreproductivetechnologyinwomenwithpolycysticovariansyndromeacohortstudy AT ahmedaboelfadlemohamed impactofhighcirculatingantimullerianhormoneonendometrialthicknessandoutcomeofassistedreproductivetechnologyinwomenwithpolycysticovariansyndromeacohortstudy AT tarekkalhussaini impactofhighcirculatingantimullerianhormoneonendometrialthicknessandoutcomeofassistedreproductivetechnologyinwomenwithpolycysticovariansyndromeacohortstudy AT redashussein impactofhighcirculatingantimullerianhormoneonendometrialthicknessandoutcomeofassistedreproductivetechnologyinwomenwithpolycysticovariansyndromeacohortstudy AT karimsabdallah impactofhighcirculatingantimullerianhormoneonendometrialthicknessandoutcomeofassistedreproductivetechnologyinwomenwithpolycysticovariansyndromeacohortstudy AT saadaamer impactofhighcirculatingantimullerianhormoneonendometrialthicknessandoutcomeofassistedreproductivetechnologyinwomenwithpolycysticovariansyndromeacohortstudy |