Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications
Intracellular micromanipulation assisted by robotic systems has valuable applications in biomedical research, such as genetic diagnosis and genome-editing tasks. However, current studies suffer from a low success rate and a large operation damage because of insufficient information on the operation...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/20/7308 |
| _version_ | 1797550514781552640 |
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| author | Wendi Gao Libo Zhao Zhuangde Jiang Dong Sun |
| author_facet | Wendi Gao Libo Zhao Zhuangde Jiang Dong Sun |
| author_sort | Wendi Gao |
| collection | DOAJ |
| description | Intracellular micromanipulation assisted by robotic systems has valuable applications in biomedical research, such as genetic diagnosis and genome-editing tasks. However, current studies suffer from a low success rate and a large operation damage because of insufficient information on the operation information of targeted specimens. The complexity of the intracellular environment causes difficulties in visualizing manipulation tools and specimens. This review summarizes and analyzes the current development of advanced biological imaging sampling and computational processing methods in intracellular micromanipulation applications. It also discusses the related limitations and future extension, providing an important reference about this field. |
| first_indexed | 2024-03-10T15:30:25Z |
| format | Article |
| id | doaj.art-47528affd50b4b3893710c0afeb1f766 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T15:30:25Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-47528affd50b4b3893710c0afeb1f7662023-11-20T17:42:10ZengMDPI AGApplied Sciences2076-34172020-10-011020730810.3390/app10207308Advanced Biological Imaging for Intracellular Micromanipulation: Methods and ApplicationsWendi Gao0Libo Zhao1Zhuangde Jiang2Dong Sun3State Key Laboratory for Manufacturing Systems Engineering and the International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, School of Mechanical Engineering, Xi’an Jiaotong University, Xi’an 710049, ChinaState Key Laboratory for Manufacturing Systems Engineering and the International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, School of Mechanical Engineering, Xi’an Jiaotong University, Xi’an 710049, ChinaState Key Laboratory for Manufacturing Systems Engineering and the International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, School of Mechanical Engineering, Xi’an Jiaotong University, Xi’an 710049, ChinaDepartment of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR 999077, ChinaIntracellular micromanipulation assisted by robotic systems has valuable applications in biomedical research, such as genetic diagnosis and genome-editing tasks. However, current studies suffer from a low success rate and a large operation damage because of insufficient information on the operation information of targeted specimens. The complexity of the intracellular environment causes difficulties in visualizing manipulation tools and specimens. This review summarizes and analyzes the current development of advanced biological imaging sampling and computational processing methods in intracellular micromanipulation applications. It also discusses the related limitations and future extension, providing an important reference about this field.https://www.mdpi.com/2076-3417/10/20/7308biological imagingcomputational imagingintracellular micromanipulation |
| spellingShingle | Wendi Gao Libo Zhao Zhuangde Jiang Dong Sun Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications Applied Sciences biological imaging computational imaging intracellular micromanipulation |
| title | Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications |
| title_full | Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications |
| title_fullStr | Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications |
| title_full_unstemmed | Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications |
| title_short | Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications |
| title_sort | advanced biological imaging for intracellular micromanipulation methods and applications |
| topic | biological imaging computational imaging intracellular micromanipulation |
| url | https://www.mdpi.com/2076-3417/10/20/7308 |
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