Focal Point of Fanconi Anemia Signaling
Among human genetic diseases, Fanconi Anemia (FA) tops all with its largest number of health complications in nearly all human organ systems, suggesting the significant roles played by FA genes in the maintenance of human health. With the accumulated research on FA, the encoded protein products by F...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/12976 |
| _version_ | 1797507699914571776 |
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| author | Sudong Zhan Jolene Siu Zhanwei Wang Herbert Yu Tedros Bezabeh Youping Deng Wei Du Peiwen Fei |
| author_facet | Sudong Zhan Jolene Siu Zhanwei Wang Herbert Yu Tedros Bezabeh Youping Deng Wei Du Peiwen Fei |
| author_sort | Sudong Zhan |
| collection | DOAJ |
| description | Among human genetic diseases, Fanconi Anemia (FA) tops all with its largest number of health complications in nearly all human organ systems, suggesting the significant roles played by FA genes in the maintenance of human health. With the accumulated research on FA, the encoded protein products by FA genes have been building up to the biggest cell defense signaling network, composed of not only 22+ FA proteins but also ATM, ATR, and many other non-FA proteins. The FA D2 group protein (FANCD2) and its paralog form the focal point of FA signaling to converge the effects of its upstream players in response to a variety of cellular insults and simultaneously with downstream players to protect humans from contracting diseases, including aging and cancer. In this review, we update and discuss how the FA signaling crucially eases cellular stresses through understanding its focal point. |
| first_indexed | 2024-03-10T04:52:09Z |
| format | Article |
| id | doaj.art-47558af968334c088fc4e18b2ae9e590 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:52:09Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-47558af968334c088fc4e18b2ae9e5902023-11-23T02:31:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122231297610.3390/ijms222312976Focal Point of Fanconi Anemia SignalingSudong Zhan0Jolene Siu1Zhanwei Wang2Herbert Yu3Tedros Bezabeh4Youping Deng5Wei Du6Peiwen Fei7University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USAStudent Research Experience Program of University of Hawaii, Honolulu, HI 96822, USAUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USAUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USADepartment of Chemistry, University of Guam, Mangilao, GU 96923, USADepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USADivision of Hematology and Oncology, University of Pittsburgh School of Medicine, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USAUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USAAmong human genetic diseases, Fanconi Anemia (FA) tops all with its largest number of health complications in nearly all human organ systems, suggesting the significant roles played by FA genes in the maintenance of human health. With the accumulated research on FA, the encoded protein products by FA genes have been building up to the biggest cell defense signaling network, composed of not only 22+ FA proteins but also ATM, ATR, and many other non-FA proteins. The FA D2 group protein (FANCD2) and its paralog form the focal point of FA signaling to converge the effects of its upstream players in response to a variety of cellular insults and simultaneously with downstream players to protect humans from contracting diseases, including aging and cancer. In this review, we update and discuss how the FA signaling crucially eases cellular stresses through understanding its focal point.https://www.mdpi.com/1422-0067/22/23/12976DNA damage responsegenome stabilitygenetic diseasefanconi anemia |
| spellingShingle | Sudong Zhan Jolene Siu Zhanwei Wang Herbert Yu Tedros Bezabeh Youping Deng Wei Du Peiwen Fei Focal Point of Fanconi Anemia Signaling International Journal of Molecular Sciences DNA damage response genome stability genetic disease fanconi anemia |
| title | Focal Point of Fanconi Anemia Signaling |
| title_full | Focal Point of Fanconi Anemia Signaling |
| title_fullStr | Focal Point of Fanconi Anemia Signaling |
| title_full_unstemmed | Focal Point of Fanconi Anemia Signaling |
| title_short | Focal Point of Fanconi Anemia Signaling |
| title_sort | focal point of fanconi anemia signaling |
| topic | DNA damage response genome stability genetic disease fanconi anemia |
| url | https://www.mdpi.com/1422-0067/22/23/12976 |
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