Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs
Pseudomonas aeruginosa ExoU, a type III secretory toxin and major virulence factor with patatin-like phospholipase activity, is responsible for acute lung injury and sepsis in immunocompromised patients. Through use of a recently updated bacterial genome database, protein sequences predicted to be h...
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| Format: | Article |
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MDPI AG
2016-10-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/8/11/307 |
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| author | Teiji Sawa Saeko Hamaoka Mao Kinoshita Atsushi Kainuma Yoshifumi Naito Koichi Akiyama Hideya Kato |
| author_facet | Teiji Sawa Saeko Hamaoka Mao Kinoshita Atsushi Kainuma Yoshifumi Naito Koichi Akiyama Hideya Kato |
| author_sort | Teiji Sawa |
| collection | DOAJ |
| description | Pseudomonas aeruginosa ExoU, a type III secretory toxin and major virulence factor with patatin-like phospholipase activity, is responsible for acute lung injury and sepsis in immunocompromised patients. Through use of a recently updated bacterial genome database, protein sequences predicted to be homologous to Ps. aeruginosa ExoU were identified in 17 other Pseudomonas species (Ps. fluorescens, Ps. lundensis, Ps. weihenstephanensis, Ps. marginalis, Ps. rhodesiae, Ps. synxantha, Ps. libanensis, Ps. extremaustralis, Ps. veronii, Ps. simiae, Ps. trivialis, Ps. tolaasii, Ps. orientalis, Ps. taetrolens, Ps. syringae, Ps. viridiflava, and Ps. cannabina) and 8 Gram-negative bacteria from three other genera (Photorhabdus, Aeromonas, and Paludibacterium). In the alignment of the predicted primary amino acid sequences used for the phylogenetic analyses, both highly conserved and nonconserved parts of the toxin were discovered among the various species. Further comparative studies of the predicted ExoU homologs should provide us with more detailed information about the unique characteristics of the Ps. aeruginosa ExoU toxin. |
| first_indexed | 2024-04-14T05:21:22Z |
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| id | doaj.art-47565d1f600944bc8319093c412204bc |
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| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-14T05:21:22Z |
| publishDate | 2016-10-01 |
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| record_format | Article |
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| spelling | doaj.art-47565d1f600944bc8319093c412204bc2022-12-22T02:10:10ZengMDPI AGToxins2072-66512016-10-0181130710.3390/toxins8110307toxins8110307Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted HomologsTeiji Sawa0Saeko Hamaoka1Mao Kinoshita2Atsushi Kainuma3Yoshifumi Naito4Koichi Akiyama5Hideya Kato6Department of Anesthesiology, School of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Anesthesiology, School of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Anesthesiology, School of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Anesthesiology, School of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Anesthesiology, School of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Anesthesiology, School of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Anesthesiology, School of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanPseudomonas aeruginosa ExoU, a type III secretory toxin and major virulence factor with patatin-like phospholipase activity, is responsible for acute lung injury and sepsis in immunocompromised patients. Through use of a recently updated bacterial genome database, protein sequences predicted to be homologous to Ps. aeruginosa ExoU were identified in 17 other Pseudomonas species (Ps. fluorescens, Ps. lundensis, Ps. weihenstephanensis, Ps. marginalis, Ps. rhodesiae, Ps. synxantha, Ps. libanensis, Ps. extremaustralis, Ps. veronii, Ps. simiae, Ps. trivialis, Ps. tolaasii, Ps. orientalis, Ps. taetrolens, Ps. syringae, Ps. viridiflava, and Ps. cannabina) and 8 Gram-negative bacteria from three other genera (Photorhabdus, Aeromonas, and Paludibacterium). In the alignment of the predicted primary amino acid sequences used for the phylogenetic analyses, both highly conserved and nonconserved parts of the toxin were discovered among the various species. Further comparative studies of the predicted ExoU homologs should provide us with more detailed information about the unique characteristics of the Ps. aeruginosa ExoU toxin.http://www.mdpi.com/2072-6651/8/11/307ExoUpatatinphospholipase A2Pseudomonas aeruginosatype III secretion system |
| spellingShingle | Teiji Sawa Saeko Hamaoka Mao Kinoshita Atsushi Kainuma Yoshifumi Naito Koichi Akiyama Hideya Kato Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs Toxins ExoU patatin phospholipase A2 Pseudomonas aeruginosa type III secretion system |
| title | Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs |
| title_full | Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs |
| title_fullStr | Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs |
| title_full_unstemmed | Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs |
| title_short | Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs |
| title_sort | pseudomonas aeruginosa type iii secretory toxin exou and its predicted homologs |
| topic | ExoU patatin phospholipase A2 Pseudomonas aeruginosa type III secretion system |
| url | http://www.mdpi.com/2072-6651/8/11/307 |
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