Salivary Amylase‐Responsive Buccal Tablets Wipe Out Chemotherapy‐Rooted Refractory Oral Mucositis
Abstract Oral mucositis (OM) is the most common and refractory complication of cancer chemotherapy and radiotherapy, severely affecting patients’ life quality, lowering treatment tolerance, and discouraging patient compliance. Current OM delivery systems mostly affect the comfort of patient use and...
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202308439 |
| _version_ | 1797254997565505536 |
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| author | Yan Zhang Taixia Wang Xiulin Dong Chunyan Zhu Qiuxia Peng Chang Liu Yifeng Zhang Fubo Chen Kun Zhang |
| author_facet | Yan Zhang Taixia Wang Xiulin Dong Chunyan Zhu Qiuxia Peng Chang Liu Yifeng Zhang Fubo Chen Kun Zhang |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | Abstract Oral mucositis (OM) is the most common and refractory complication of cancer chemotherapy and radiotherapy, severely affecting patients’ life quality, lowering treatment tolerance, and discouraging patient compliance. Current OM delivery systems mostly affect the comfort of patient use and lead to poor compliance and unsatisfactory effects. Herein, salivary amylases (SAs)‐responsive buccal tablets consisting of porous manganese‐substituted Prussian blue (PMPB) nanocubes (NCs), anti‐inflammatory apremilast (Apr) and starch controller have been engineered. PMPB NCs with large surface area can serve as carriers to load Apr, and their multienzyme‐mimicking activity enables them to scavenge reactive oxygen species (ROS), which thus synergize with Apr to mitigate inflammation. More significantly, the starch controller can respond to abundant SAs in the oral cavity and realize the cascade, continuous, and complete drug release after enzymatic decomposition, which not only aids with high tissue affinity to prolong the resistance time but also improves the comfort of use. The preclinical study reveals that contributed by the above actions, such buccal tablets mitigate inflammation, promote endothelium proliferation and migration, and accelerate wound healing for repressing chemotherapy‐originated intractable OM with positive oral microenvironment and shorter recovery time, thus holding high potentials in clinical translation. |
| first_indexed | 2024-04-24T21:58:51Z |
| format | Article |
| id | doaj.art-4756bd9911174fbf9815a95963d12693 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-24T21:58:51Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-4756bd9911174fbf9815a95963d126932024-03-20T12:56:12ZengWileyAdvanced Science2198-38442024-03-011111n/an/a10.1002/advs.202308439Salivary Amylase‐Responsive Buccal Tablets Wipe Out Chemotherapy‐Rooted Refractory Oral MucositisYan Zhang0Taixia Wang1Xiulin Dong2Chunyan Zhu3Qiuxia Peng4Chang Liu5Yifeng Zhang6Fubo Chen7Kun Zhang8Department of Medical Ultrasound and Department of Stomatology Shanghai Tenth People's Hospital Tongji University School of Medicine Tongji University NO. 301 Yan‐chang‐zhong Road Shanghai 200072 ChinaDepartment of Medical Ultrasound and Department of Stomatology Shanghai Tenth People's Hospital Tongji University School of Medicine Tongji University NO. 301 Yan‐chang‐zhong Road Shanghai 200072 ChinaDepartment of Pharmacy and Central Laboratory Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu 610072 ChinaDepartment of Medical Ultrasound and Department of Stomatology Shanghai Tenth People's Hospital Tongji University School of Medicine Tongji University NO. 301 Yan‐chang‐zhong Road Shanghai 200072 ChinaDepartment of Medical Ultrasound and Department of Stomatology Shanghai Tenth People's Hospital Tongji University School of Medicine Tongji University NO. 301 Yan‐chang‐zhong Road Shanghai 200072 ChinaDepartment of Medical Ultrasound and Department of Stomatology Shanghai Tenth People's Hospital Tongji University School of Medicine Tongji University NO. 301 Yan‐chang‐zhong Road Shanghai 200072 ChinaDepartment of Medical Ultrasound and Department of Stomatology Shanghai Tenth People's Hospital Tongji University School of Medicine Tongji University NO. 301 Yan‐chang‐zhong Road Shanghai 200072 ChinaDepartment of Medical Ultrasound and Department of Stomatology Shanghai Tenth People's Hospital Tongji University School of Medicine Tongji University NO. 301 Yan‐chang‐zhong Road Shanghai 200072 ChinaDepartment of Pharmacy and Central Laboratory Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu 610072 ChinaAbstract Oral mucositis (OM) is the most common and refractory complication of cancer chemotherapy and radiotherapy, severely affecting patients’ life quality, lowering treatment tolerance, and discouraging patient compliance. Current OM delivery systems mostly affect the comfort of patient use and lead to poor compliance and unsatisfactory effects. Herein, salivary amylases (SAs)‐responsive buccal tablets consisting of porous manganese‐substituted Prussian blue (PMPB) nanocubes (NCs), anti‐inflammatory apremilast (Apr) and starch controller have been engineered. PMPB NCs with large surface area can serve as carriers to load Apr, and their multienzyme‐mimicking activity enables them to scavenge reactive oxygen species (ROS), which thus synergize with Apr to mitigate inflammation. More significantly, the starch controller can respond to abundant SAs in the oral cavity and realize the cascade, continuous, and complete drug release after enzymatic decomposition, which not only aids with high tissue affinity to prolong the resistance time but also improves the comfort of use. The preclinical study reveals that contributed by the above actions, such buccal tablets mitigate inflammation, promote endothelium proliferation and migration, and accelerate wound healing for repressing chemotherapy‐originated intractable OM with positive oral microenvironment and shorter recovery time, thus holding high potentials in clinical translation.https://doi.org/10.1002/advs.202308439anti‐inflammatorybuccal tabletsrefractory oral mucositissalivary amylase responsewound healing |
| spellingShingle | Yan Zhang Taixia Wang Xiulin Dong Chunyan Zhu Qiuxia Peng Chang Liu Yifeng Zhang Fubo Chen Kun Zhang Salivary Amylase‐Responsive Buccal Tablets Wipe Out Chemotherapy‐Rooted Refractory Oral Mucositis Advanced Science anti‐inflammatory buccal tablets refractory oral mucositis salivary amylase response wound healing |
| title | Salivary Amylase‐Responsive Buccal Tablets Wipe Out Chemotherapy‐Rooted Refractory Oral Mucositis |
| title_full | Salivary Amylase‐Responsive Buccal Tablets Wipe Out Chemotherapy‐Rooted Refractory Oral Mucositis |
| title_fullStr | Salivary Amylase‐Responsive Buccal Tablets Wipe Out Chemotherapy‐Rooted Refractory Oral Mucositis |
| title_full_unstemmed | Salivary Amylase‐Responsive Buccal Tablets Wipe Out Chemotherapy‐Rooted Refractory Oral Mucositis |
| title_short | Salivary Amylase‐Responsive Buccal Tablets Wipe Out Chemotherapy‐Rooted Refractory Oral Mucositis |
| title_sort | salivary amylase responsive buccal tablets wipe out chemotherapy rooted refractory oral mucositis |
| topic | anti‐inflammatory buccal tablets refractory oral mucositis salivary amylase response wound healing |
| url | https://doi.org/10.1002/advs.202308439 |
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