Characteristics of Chronic Lymphocytic Leukemia in Sudanese Patients
Objective: Our study aimed to characterize clinical, hematological and Immunophenotyping patterns in Sudanese patients with Chronic Lymphocytic Leukemia. Methods: A cross-sectional study was conducted in Khartoum state, Sudan, during the period from April 2017 to April 2018, involved 110 CLL patien...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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West Asia Organization for Cancer Prevention
2022-08-01
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| Series: | Asian Pacific Journal of Cancer Care |
| Subjects: | |
| Online Access: | http://www.waocp.com/journal/index.php/apjcc/article/view/885 |
| _version_ | 1797342234492796928 |
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| author | Ameen Abdulaziz Basabaeen Enaam Abdelrhman Abdelgader Ebtihal Ahmed Babekir Nour Mahmoud Abdelateif Sadia Osman Abdelrahim Osama Ali Altayeb Eman Abbass Fadul Hussam Ali Osman Salem Ahmed Bamusa Ibrahim Khider Ibrahim |
| author_facet | Ameen Abdulaziz Basabaeen Enaam Abdelrhman Abdelgader Ebtihal Ahmed Babekir Nour Mahmoud Abdelateif Sadia Osman Abdelrahim Osama Ali Altayeb Eman Abbass Fadul Hussam Ali Osman Salem Ahmed Bamusa Ibrahim Khider Ibrahim |
| author_sort | Ameen Abdulaziz Basabaeen |
| collection | DOAJ |
| description | Objective: Our study aimed to characterize clinical, hematological and Immunophenotyping patterns in Sudanese patients with Chronic Lymphocytic Leukemia.
Methods: A cross-sectional study was conducted in Khartoum state, Sudan, during the period from April 2017 to April 2018, involved 110 CLL patients. Physical examination, Complete Blood Count and Immunophenotyping were performed for all patients to confirm the diagnosis. Clinical staging such as Rai and Binet stages were applied. The statistical analysis was performed by using SPSS version 23.0.
Results: In this study, 71.8% were males and 28.2% were females. Lymphadenopathy, splenomegaly, hepatomegaly, leukocytosis, thrombocytopenia, and anemia were seen in 71%, 49%, 13%, 60.9%, 39% and 34.5% of patients respectively. However, about 90% of patients displayed an advanced Rai risk stage and 70% were at Binet stage B or C. All CLL samples expressed CD45, CD19 and CD20. All the CLL cases were negative for the T-cell marker CD3.CD5 was expressed in 80% patients; CD23 was expressed in 92.7% patients. CD22, CD79b and FMC7 were negative in 91.8%, 77.3%, and 96.4% of patients respectively.
Conclusions: CLL in Sudan is a disease of the elderly and more frequently in males than females. The incidence at young patients was higher than those reported by Western studies. Most of our patients presented advanced Rai and Binet stages. CD22 may be a highly specific marker for diagnosing CLL in Sudanese patients and should be included in all diagnostic panels used to differentiate CLL from other B cell lymphoproliferative disorders in Sudan. |
| first_indexed | 2024-03-08T10:30:21Z |
| format | Article |
| id | doaj.art-47579f529218484ba22b6569912216b6 |
| institution | Directory Open Access Journal |
| issn | 2588-3682 |
| language | English |
| last_indexed | 2024-03-08T10:30:21Z |
| publishDate | 2022-08-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Care |
| spelling | doaj.art-47579f529218484ba22b6569912216b62024-01-27T05:44:14ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Care2588-36822022-08-017346747410.31557/apjcc.2022.7.3.467-474885Characteristics of Chronic Lymphocytic Leukemia in Sudanese PatientsAmeen Abdulaziz Basabaeen0Enaam Abdelrhman Abdelgader1Ebtihal Ahmed Babekir2Nour Mahmoud Abdelateif3Sadia Osman Abdelrahim4Osama Ali Altayeb5Eman Abbass Fadul6Hussam Ali Osman7Salem Ahmed Bamusa8Ibrahim Khider Ibrahim9Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan. Ministry of Health & Population, Hadhramout, Yemen.Department of Pathology, Faculty of Medicine, Al Neelain University, Khartoum, Sudan.Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.Flow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis, Khartoum, Sudan.Flow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis, Khartoum, Sudan.School of Pharmacy, Ahfad University for Women, Sudan. Khawarizmi International College, Abu Dhabi.Ministry of Health & Population, Hadhramout, Yemen.Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.Objective: Our study aimed to characterize clinical, hematological and Immunophenotyping patterns in Sudanese patients with Chronic Lymphocytic Leukemia. Methods: A cross-sectional study was conducted in Khartoum state, Sudan, during the period from April 2017 to April 2018, involved 110 CLL patients. Physical examination, Complete Blood Count and Immunophenotyping were performed for all patients to confirm the diagnosis. Clinical staging such as Rai and Binet stages were applied. The statistical analysis was performed by using SPSS version 23.0. Results: In this study, 71.8% were males and 28.2% were females. Lymphadenopathy, splenomegaly, hepatomegaly, leukocytosis, thrombocytopenia, and anemia were seen in 71%, 49%, 13%, 60.9%, 39% and 34.5% of patients respectively. However, about 90% of patients displayed an advanced Rai risk stage and 70% were at Binet stage B or C. All CLL samples expressed CD45, CD19 and CD20. All the CLL cases were negative for the T-cell marker CD3.CD5 was expressed in 80% patients; CD23 was expressed in 92.7% patients. CD22, CD79b and FMC7 were negative in 91.8%, 77.3%, and 96.4% of patients respectively. Conclusions: CLL in Sudan is a disease of the elderly and more frequently in males than females. The incidence at young patients was higher than those reported by Western studies. Most of our patients presented advanced Rai and Binet stages. CD22 may be a highly specific marker for diagnosing CLL in Sudanese patients and should be included in all diagnostic panels used to differentiate CLL from other B cell lymphoproliferative disorders in Sudan.http://www.waocp.com/journal/index.php/apjcc/article/view/885cll, clinical, staging system, hematological, immunophenotype |
| spellingShingle | Ameen Abdulaziz Basabaeen Enaam Abdelrhman Abdelgader Ebtihal Ahmed Babekir Nour Mahmoud Abdelateif Sadia Osman Abdelrahim Osama Ali Altayeb Eman Abbass Fadul Hussam Ali Osman Salem Ahmed Bamusa Ibrahim Khider Ibrahim Characteristics of Chronic Lymphocytic Leukemia in Sudanese Patients Asian Pacific Journal of Cancer Care cll, clinical, staging system, hematological, immunophenotype |
| title | Characteristics of Chronic Lymphocytic Leukemia in Sudanese Patients |
| title_full | Characteristics of Chronic Lymphocytic Leukemia in Sudanese Patients |
| title_fullStr | Characteristics of Chronic Lymphocytic Leukemia in Sudanese Patients |
| title_full_unstemmed | Characteristics of Chronic Lymphocytic Leukemia in Sudanese Patients |
| title_short | Characteristics of Chronic Lymphocytic Leukemia in Sudanese Patients |
| title_sort | characteristics of chronic lymphocytic leukemia in sudanese patients |
| topic | cll, clinical, staging system, hematological, immunophenotype |
| url | http://www.waocp.com/journal/index.php/apjcc/article/view/885 |
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