Neuro-allergology: Mast cell–nerve cross-talk
Mast cells (MCs) are derived from hematopoietic stem cells in the bone marrow, and their maturation is regulated by the tissue environment, such as the skin, lung and gut, leading to host defense. Peripheral nerve fibers located in various tissues are involved in diverse physiological and pathologic...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893022000405 |
| _version_ | 1818219224778145792 |
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| author | Shota Toyoshima Yoshimichi Okayama |
| author_facet | Shota Toyoshima Yoshimichi Okayama |
| author_sort | Shota Toyoshima |
| collection | DOAJ |
| description | Mast cells (MCs) are derived from hematopoietic stem cells in the bone marrow, and their maturation is regulated by the tissue environment, such as the skin, lung and gut, leading to host defense. Peripheral nerve fibers located in various tissues are involved in diverse physiological and pathological processes. Anatomical relationships between MCs and nerve fibers were reported to have been observed in various organs. Moreover, MCs are positive for a large number of receptors for classical neurotransmitters (e.g., acetylcholine and corticotropin-releasing hormone) and neuropeptides (e.g., substance P, calcitonin gene-related peptides and hemokinin), and MC's functions are regulated by those nerve-derived factors. Also, histamine and proteases produced and released by MCs modulate nerve fiber functions. This functional cross-talk between MCs and nerve fibers can play physiological and pathological roles. MCs are key effector cells of allergic inflammation, such as atopic dermatitis, airway inflammation and food allergy. Here, we summarize and discuss the molecular mechanisms underlying the functional and anatomical cross-talk between MCs and nerve fibers in allergic inflamed tissues. |
| first_indexed | 2024-12-12T07:36:16Z |
| format | Article |
| id | doaj.art-475901252acb46a39dadc75fe7e4a718 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-12T07:36:16Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-475901252acb46a39dadc75fe7e4a7182022-12-22T00:32:55ZengElsevierAllergology International1323-89302022-07-01713288293Neuro-allergology: Mast cell–nerve cross-talkShota Toyoshima0Yoshimichi Okayama1Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan; Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, JapanAllergy and Immunology Research Project Team, Research Institute of Medical Science, Center for Medical Education, Nihon University School of Medicine, Tokyo, Japan; Center for Allergy, Nihon University Itabashi Hospital, Tokyo, Japan; Corresponding author. Allergy and Immunology Research Project Team, Research Institute of Medical Science, Center for Medical Education, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-Ku, Tokyo 173-8610, Japan.Mast cells (MCs) are derived from hematopoietic stem cells in the bone marrow, and their maturation is regulated by the tissue environment, such as the skin, lung and gut, leading to host defense. Peripheral nerve fibers located in various tissues are involved in diverse physiological and pathological processes. Anatomical relationships between MCs and nerve fibers were reported to have been observed in various organs. Moreover, MCs are positive for a large number of receptors for classical neurotransmitters (e.g., acetylcholine and corticotropin-releasing hormone) and neuropeptides (e.g., substance P, calcitonin gene-related peptides and hemokinin), and MC's functions are regulated by those nerve-derived factors. Also, histamine and proteases produced and released by MCs modulate nerve fiber functions. This functional cross-talk between MCs and nerve fibers can play physiological and pathological roles. MCs are key effector cells of allergic inflammation, such as atopic dermatitis, airway inflammation and food allergy. Here, we summarize and discuss the molecular mechanisms underlying the functional and anatomical cross-talk between MCs and nerve fibers in allergic inflamed tissues.http://www.sciencedirect.com/science/article/pii/S1323893022000405Allergic inflammationCross-talkMast cellNerveNeuropeptide |
| spellingShingle | Shota Toyoshima Yoshimichi Okayama Neuro-allergology: Mast cell–nerve cross-talk Allergology International Allergic inflammation Cross-talk Mast cell Nerve Neuropeptide |
| title | Neuro-allergology: Mast cell–nerve cross-talk |
| title_full | Neuro-allergology: Mast cell–nerve cross-talk |
| title_fullStr | Neuro-allergology: Mast cell–nerve cross-talk |
| title_full_unstemmed | Neuro-allergology: Mast cell–nerve cross-talk |
| title_short | Neuro-allergology: Mast cell–nerve cross-talk |
| title_sort | neuro allergology mast cell nerve cross talk |
| topic | Allergic inflammation Cross-talk Mast cell Nerve Neuropeptide |
| url | http://www.sciencedirect.com/science/article/pii/S1323893022000405 |
| work_keys_str_mv | AT shotatoyoshima neuroallergologymastcellnervecrosstalk AT yoshimichiokayama neuroallergologymastcellnervecrosstalk |