Feasibility of restorative proctocolectomy in patients with ulcerative colitis-associated lower rectal cancer: A retrospective study
Summary: Background/Objective: Restorative proctocolectomy (RP) may improve quality of life in patients with ulcerative colitis (UC)-associated lower rectal cancer to a greater extent than total proctocolectomy. However, patients with UC-associated cancer often have flat mucosal lesions that make i...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Asian Journal of Surgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958417305833 |
| _version_ | 1818307561285222400 |
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| author | Shinnosuke Hotta Yoshifumi Shimada Mae Nakano Saki Yamada Kaoru Abe Hidehito Oyanagi Ryoma Yagi Yosuke Tajima Masato Nakano Hitoshi Kameyama Masayuki Nagahashi Jun Sakata Takashi Kobayashi Toshifumi Wakai |
| author_facet | Shinnosuke Hotta Yoshifumi Shimada Mae Nakano Saki Yamada Kaoru Abe Hidehito Oyanagi Ryoma Yagi Yosuke Tajima Masato Nakano Hitoshi Kameyama Masayuki Nagahashi Jun Sakata Takashi Kobayashi Toshifumi Wakai |
| author_sort | Shinnosuke Hotta |
| collection | DOAJ |
| description | Summary: Background/Objective: Restorative proctocolectomy (RP) may improve quality of life in patients with ulcerative colitis (UC)-associated lower rectal cancer to a greater extent than total proctocolectomy. However, patients with UC-associated cancer often have flat mucosal lesions that make it extremely difficult to endoscopically delineate the tumor margins. Therefore, there is a potential risk of residual tumor and local recurrence after RP in patients with UC-associated lower rectal cancer. The aim of this study was to assess the feasibility of RP in patients with UC-associated cancer of the lower rectum. Methods: We retrospectively identified nine patients who had undergone RP for UC-associated lower rectal cancer at the Niigata University Medical and Dental Hospital between January 2000 and December 2016. The incidence of flat mucosal cancer, distal margin status, and oncologic outcomes were evaluated in the nine patients. Results: Eight (89%) of the nine patients had flat mucosal cancer in the lower rectum. The median length of the distal margin was 22 mm (range 0–55 mm). No patient developed local or distant recurrence during follow-up. One patient had a positive distal margin. This patient underwent annual pouchoscopy, but had no local recurrence and died of pancreatic cancer 81 months after RP. The remaining eight patients were alive at the final observation. Five-year and 10-year overall survival rates in the nine patients were 100% and 66.7%, respectively. Conclusion: Patients with UC-associated lower rectal cancer often have lesions of the flat mucosal type. However, RP is feasible and not necessarily contraindicated in such patients. Keywords: inflammatory bowel disease, rectal cancer, restorative proctocolectomy, ulcerative colitis, ulcerative colitis-associated cancer |
| first_indexed | 2024-12-13T07:00:20Z |
| format | Article |
| id | doaj.art-475a50551130491c9ce69ca646c44767 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-13T07:00:20Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-475a50551130491c9ce69ca646c447672022-12-21T23:55:57ZengElsevierAsian Journal of Surgery1015-95842019-01-01421267273Feasibility of restorative proctocolectomy in patients with ulcerative colitis-associated lower rectal cancer: A retrospective studyShinnosuke Hotta0Yoshifumi Shimada1Mae Nakano2Saki Yamada3Kaoru Abe4Hidehito Oyanagi5Ryoma Yagi6Yosuke Tajima7Masato Nakano8Hitoshi Kameyama9Masayuki Nagahashi10Jun Sakata11Takashi Kobayashi12Toshifumi Wakai13Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanCorresponding author. Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan. Fax: +81 25 227 0779.; Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata 951-8510, JapanSummary: Background/Objective: Restorative proctocolectomy (RP) may improve quality of life in patients with ulcerative colitis (UC)-associated lower rectal cancer to a greater extent than total proctocolectomy. However, patients with UC-associated cancer often have flat mucosal lesions that make it extremely difficult to endoscopically delineate the tumor margins. Therefore, there is a potential risk of residual tumor and local recurrence after RP in patients with UC-associated lower rectal cancer. The aim of this study was to assess the feasibility of RP in patients with UC-associated cancer of the lower rectum. Methods: We retrospectively identified nine patients who had undergone RP for UC-associated lower rectal cancer at the Niigata University Medical and Dental Hospital between January 2000 and December 2016. The incidence of flat mucosal cancer, distal margin status, and oncologic outcomes were evaluated in the nine patients. Results: Eight (89%) of the nine patients had flat mucosal cancer in the lower rectum. The median length of the distal margin was 22 mm (range 0–55 mm). No patient developed local or distant recurrence during follow-up. One patient had a positive distal margin. This patient underwent annual pouchoscopy, but had no local recurrence and died of pancreatic cancer 81 months after RP. The remaining eight patients were alive at the final observation. Five-year and 10-year overall survival rates in the nine patients were 100% and 66.7%, respectively. Conclusion: Patients with UC-associated lower rectal cancer often have lesions of the flat mucosal type. However, RP is feasible and not necessarily contraindicated in such patients. Keywords: inflammatory bowel disease, rectal cancer, restorative proctocolectomy, ulcerative colitis, ulcerative colitis-associated cancerhttp://www.sciencedirect.com/science/article/pii/S1015958417305833 |
| spellingShingle | Shinnosuke Hotta Yoshifumi Shimada Mae Nakano Saki Yamada Kaoru Abe Hidehito Oyanagi Ryoma Yagi Yosuke Tajima Masato Nakano Hitoshi Kameyama Masayuki Nagahashi Jun Sakata Takashi Kobayashi Toshifumi Wakai Feasibility of restorative proctocolectomy in patients with ulcerative colitis-associated lower rectal cancer: A retrospective study Asian Journal of Surgery |
| title | Feasibility of restorative proctocolectomy in patients with ulcerative colitis-associated lower rectal cancer: A retrospective study |
| title_full | Feasibility of restorative proctocolectomy in patients with ulcerative colitis-associated lower rectal cancer: A retrospective study |
| title_fullStr | Feasibility of restorative proctocolectomy in patients with ulcerative colitis-associated lower rectal cancer: A retrospective study |
| title_full_unstemmed | Feasibility of restorative proctocolectomy in patients with ulcerative colitis-associated lower rectal cancer: A retrospective study |
| title_short | Feasibility of restorative proctocolectomy in patients with ulcerative colitis-associated lower rectal cancer: A retrospective study |
| title_sort | feasibility of restorative proctocolectomy in patients with ulcerative colitis associated lower rectal cancer a retrospective study |
| url | http://www.sciencedirect.com/science/article/pii/S1015958417305833 |
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