Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease
Ubiquitination is a posttranslational modification of proteins that significantly affects protein stability and function. The specificity of substrate recognition is determined by ubiquitin E3 ligase during ubiquitination. Human Deltex (DTX) protein family, which functions as ubiquitin E3 ligases, c...
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| Format: | Article |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.706997/full |
| _version_ | 1819083899992539136 |
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| author | Lidong Wang Xiaodan Sun Jingni He Zhen Liu |
| author_facet | Lidong Wang Xiaodan Sun Jingni He Zhen Liu |
| author_sort | Lidong Wang |
| collection | DOAJ |
| description | Ubiquitination is a posttranslational modification of proteins that significantly affects protein stability and function. The specificity of substrate recognition is determined by ubiquitin E3 ligase during ubiquitination. Human Deltex (DTX) protein family, which functions as ubiquitin E3 ligases, comprises five members, namely, DTX1, DTX2, DTX3, DTX3L, and DTX4. The characteristics and functional diversity of the DTX family proteins have attracted significant attention over the last decade. DTX proteins have several physiological and pathological roles and are closely associated with cell signal transduction, growth, differentiation, and apoptosis, as well as the occurrence and development of various tumors. Although they have been extensively studied in various species, data on structural features, biological functions, and potential mechanisms of action of the DTX family proteins remain limited. In this review, recent research progress on each member of the DTX family is summarized, providing insights into future research directions and potential strategies in disease diagnosis and therapy. |
| first_indexed | 2024-12-21T20:39:54Z |
| format | Article |
| id | doaj.art-475cdea34ee24571887f9e6b7198e493 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-21T20:39:54Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-475cdea34ee24571887f9e6b7198e4932022-12-21T18:51:00ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-08-01910.3389/fcell.2021.706997706997Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and DiseaseLidong Wang0Xiaodan Sun1Jingni He2Zhen Liu3Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaPostdoctoral Research Workstation, Jilin Cancer Hospital, Changchun, ChinaDepartment of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaUbiquitination is a posttranslational modification of proteins that significantly affects protein stability and function. The specificity of substrate recognition is determined by ubiquitin E3 ligase during ubiquitination. Human Deltex (DTX) protein family, which functions as ubiquitin E3 ligases, comprises five members, namely, DTX1, DTX2, DTX3, DTX3L, and DTX4. The characteristics and functional diversity of the DTX family proteins have attracted significant attention over the last decade. DTX proteins have several physiological and pathological roles and are closely associated with cell signal transduction, growth, differentiation, and apoptosis, as well as the occurrence and development of various tumors. Although they have been extensively studied in various species, data on structural features, biological functions, and potential mechanisms of action of the DTX family proteins remain limited. In this review, recent research progress on each member of the DTX family is summarized, providing insights into future research directions and potential strategies in disease diagnosis and therapy.https://www.frontiersin.org/articles/10.3389/fcell.2021.706997/fullDeltex family proteinsubiquitinationubiquitin E3 ligaseubiquitin codeprotein homeostasispost-translational modification |
| spellingShingle | Lidong Wang Xiaodan Sun Jingni He Zhen Liu Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease Frontiers in Cell and Developmental Biology Deltex family proteins ubiquitination ubiquitin E3 ligase ubiquitin code protein homeostasis post-translational modification |
| title | Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease |
| title_full | Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease |
| title_fullStr | Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease |
| title_full_unstemmed | Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease |
| title_short | Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease |
| title_sort | functions and molecular mechanisms of deltex family ubiquitin e3 ligases in development and disease |
| topic | Deltex family proteins ubiquitination ubiquitin E3 ligase ubiquitin code protein homeostasis post-translational modification |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.706997/full |
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