Clinicopathological, Biochemical, and Sonographic Features of Thyroid Nodule Predictive of Malignancy among Adult Filipino Patients in a Tertiary Hospital in the Philippines
BackgroundThyroid nodules may harbor cancer in 5% to 15% of cases. Specific clinical and sonographic features predictive of malignancy have been investigated in various populations, but due to differences in epidemiology, risk factors and iodine nutrition status, these predictors may not be valid in...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2014-12-01
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| Series: | Endocrinology and Metabolism |
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| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-29-489.pdf |
| _version_ | 1828950744499224576 |
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| author | Edwin Jadulco Cañete Cherrie Mae Sison-Peña Cecilia Alegado Jimeno |
| author_facet | Edwin Jadulco Cañete Cherrie Mae Sison-Peña Cecilia Alegado Jimeno |
| author_sort | Edwin Jadulco Cañete |
| collection | DOAJ |
| description | BackgroundThyroid nodules may harbor cancer in 5% to 15% of cases. Specific clinical and sonographic features predictive of malignancy have been investigated in various populations, but due to differences in epidemiology, risk factors and iodine nutrition status, these predictors may not be valid in the Philippines. This study determined the clinicopathological, biochemical, and sonographic features of thyroid nodules predictive of malignancy among adult Filipino patients at the University of the Philippines-Philippine General Hospital (UP-PGH).MethodsWe reviewed the medical records of Filipino patients ≥19 years of age who underwent thyroid surgery in UP-PGH from 2008 to 2011.ResultsA total of 837 of 1,670 patients (50.1%) were enrolled in the study, which included 417 benign and 420 malignant tumors. The mean age at diagnosis was 38±11 years, with female predominance. Multiple logistic regression analysis showed that the presence of a hard or firm nodule (odds ratio [OR], 58.8, P<0.001; OR, 12.8, P<0.001), presence of microcalcifications (OR, 11.1; P<0.001), irregular margins on ultrasound (OR, 4.5; P<0.001), and absence of associated symptoms (OR, 2.3; P<0.002) increased significantly the likelihood of thyroid malignancy.ConclusionSimilar to international data, the absence of associated symptoms, firm to hard thyroid nodules, and the presence of microcalcifications and irregular margins were significant predictors of thyroid malignancy. |
| first_indexed | 2024-12-14T06:27:52Z |
| format | Article |
| id | doaj.art-475ce130e01d49a985299b5b76f57ee1 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-14T06:27:52Z |
| publishDate | 2014-12-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-475ce130e01d49a985299b5b76f57ee12022-12-21T23:13:37ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782014-12-0129448949710.3803/EnM.2014.29.4.48921211Clinicopathological, Biochemical, and Sonographic Features of Thyroid Nodule Predictive of Malignancy among Adult Filipino Patients in a Tertiary Hospital in the PhilippinesEdwin Jadulco CañeteCherrie Mae Sison-PeñaCecilia Alegado JimenoBackgroundThyroid nodules may harbor cancer in 5% to 15% of cases. Specific clinical and sonographic features predictive of malignancy have been investigated in various populations, but due to differences in epidemiology, risk factors and iodine nutrition status, these predictors may not be valid in the Philippines. This study determined the clinicopathological, biochemical, and sonographic features of thyroid nodules predictive of malignancy among adult Filipino patients at the University of the Philippines-Philippine General Hospital (UP-PGH).MethodsWe reviewed the medical records of Filipino patients ≥19 years of age who underwent thyroid surgery in UP-PGH from 2008 to 2011.ResultsA total of 837 of 1,670 patients (50.1%) were enrolled in the study, which included 417 benign and 420 malignant tumors. The mean age at diagnosis was 38±11 years, with female predominance. Multiple logistic regression analysis showed that the presence of a hard or firm nodule (odds ratio [OR], 58.8, P<0.001; OR, 12.8, P<0.001), presence of microcalcifications (OR, 11.1; P<0.001), irregular margins on ultrasound (OR, 4.5; P<0.001), and absence of associated symptoms (OR, 2.3; P<0.002) increased significantly the likelihood of thyroid malignancy.ConclusionSimilar to international data, the absence of associated symptoms, firm to hard thyroid nodules, and the presence of microcalcifications and irregular margins were significant predictors of thyroid malignancy.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-29-489.pdfThyroid noduleThyroid malignancyUltrasonography |
| spellingShingle | Edwin Jadulco Cañete Cherrie Mae Sison-Peña Cecilia Alegado Jimeno Clinicopathological, Biochemical, and Sonographic Features of Thyroid Nodule Predictive of Malignancy among Adult Filipino Patients in a Tertiary Hospital in the Philippines Endocrinology and Metabolism Thyroid nodule Thyroid malignancy Ultrasonography |
| title | Clinicopathological, Biochemical, and Sonographic Features of Thyroid Nodule Predictive of Malignancy among Adult Filipino Patients in a Tertiary Hospital in the Philippines |
| title_full | Clinicopathological, Biochemical, and Sonographic Features of Thyroid Nodule Predictive of Malignancy among Adult Filipino Patients in a Tertiary Hospital in the Philippines |
| title_fullStr | Clinicopathological, Biochemical, and Sonographic Features of Thyroid Nodule Predictive of Malignancy among Adult Filipino Patients in a Tertiary Hospital in the Philippines |
| title_full_unstemmed | Clinicopathological, Biochemical, and Sonographic Features of Thyroid Nodule Predictive of Malignancy among Adult Filipino Patients in a Tertiary Hospital in the Philippines |
| title_short | Clinicopathological, Biochemical, and Sonographic Features of Thyroid Nodule Predictive of Malignancy among Adult Filipino Patients in a Tertiary Hospital in the Philippines |
| title_sort | clinicopathological biochemical and sonographic features of thyroid nodule predictive of malignancy among adult filipino patients in a tertiary hospital in the philippines |
| topic | Thyroid nodule Thyroid malignancy Ultrasonography |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-29-489.pdf |
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