A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers

A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers

ABSTRACT Fijiviruses replicate and package their genomes within viroplasms in a process involving RNA-RNA and RNA-protein interactions. Here, we demonstrate that the 24 C-terminal residues (C-arm) of the P9-1 major viroplasm protein of the mal de Río Cuarto virus (MRCV) are required for its multimer...

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Bibliographic Details
Main Authors: Gabriela Llauger, Roberto Melero, Demián Monti, Gabriela Sycz, Cristián Huck-Iriart, María L. Cerutti, Sebastián Klinke, Evelyn Mikkelsen, Ariel Tijman, Rocío Arranz, Victoria Alfonso, Sofía M. Arellano, Fernando A. Goldbaum, Yann G. J. Sterckx, José-María Carazo, Sergio B. Kaufman, Pablo D. Dans, Mariana del Vas, Lisandro H. Otero
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
plant virus
reovirus
double-stranded RNA virus
viroplasm
protein-nucleic acid interaction
ATPase
Online Access:https://journals.asm.org/doi/10.1128/mbio.00023-23

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