Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo

Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo

Pancreatic cancer remains a recalcitrant neoplasm associated with chemoresistance and high fatality. Because it is frequently resistant to apoptosis, exploiting autophagic cell death could offer a new treatment approach. We repurpose echinomycin, an antibiotic encapsulated within a syndecan-1 active...

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Bibliographic Details
Main Authors: Alexandra Thomas, Abhilash Samykutty, Jorge G. Gomez-Gutierrez, Wenyuan Yin, Michael E. Egger, Molly McNally, Phillip Chuong, William M. MacCuaig, Sabrin Albeituni, Matthew Zeiderman, Min Li, Barish H. Edil, William E. Grizzle, Kelly M. McMasters, Lacey R. McNally
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
echinomycin
autophagy
autophagic cell death
active targeted liposome
pancreatic cancer
alternative cancer therapy
Online Access:https://www.mdpi.com/2072-6694/12/8/2279

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