Frailty syndrome and end-stage kidney disease outcomes at a Latin American dialysis center
Introduction. Frailty syndrome generates a high risk of adverse outcomes and mortality, and its prevalence is elevated in patients with end-stage kidney disease. Few studies have reported the prevalence and outcomes of frailty in populations from less developed countries. Objective. To identify the...
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| Format: | Article |
| Language: | English |
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Instituto Nacional de Salud
2023-12-01
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| Series: | Biomédica: revista del Instituto Nacional de Salud |
| Subjects: | |
| Online Access: | https://revistabiomedica.org/index.php/biomedica/article/view/7057 |
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| author | Luis David Moreno Carlos Eduardo Ruiz Juan Carlos Urrego Miguel Oswaldo Cadena Silvia José Maldonado Daniel Andrés Niño Andrea Maldonado |
| author_facet | Luis David Moreno Carlos Eduardo Ruiz Juan Carlos Urrego Miguel Oswaldo Cadena Silvia José Maldonado Daniel Andrés Niño Andrea Maldonado |
| author_sort | Luis David Moreno |
| collection | DOAJ |
| description | Introduction. Frailty syndrome generates a high risk of adverse outcomes and mortality, and its prevalence is elevated in patients with end-stage kidney disease. Few studies have reported the prevalence and outcomes of frailty in populations from less developed countries.
Objective. To identify the clinical outcomes and factors associated with the frailty syndrome in patients with stage five chronic kidney disease who started renal replacement therapy – both hemodialysis and peritoneal dialysis– in a dialysis center in Bucaramanga, Colombia.
Materials and methods. This was a prospective study of patients with end-stage kidney disease who initiated dialysis at a center in Colombia and had a twelve-month follow-up.
Results. The overall frailty prevalence was 50.47% and two out of three patients older than 65 years had the syndrome. We found significantly higher followup mortality among patients with frailty: odds ratio of 2.95 (CI: 1.07- 8.13; p=0.036) in unadjusted analysis.
Conclusions. Literature shows that compared to developed nations, Latin American adults are facing a higher prevalence of chronic diseases, and frailty syndrome is raising. In this study, according to the FRAIL scale, having a frailty syndrome predicts a higher mortality; hypoalbuminemia and low creatinine levels at the beginning of dialysis could act as predictors of its diagnosis. |
| first_indexed | 2024-03-08T14:39:15Z |
| format | Article |
| id | doaj.art-4761690ecf454ba39933e2b0750c5da6 |
| institution | Directory Open Access Journal |
| issn | 0120-4157 2590-7379 |
| language | English |
| last_indexed | 2024-03-08T14:39:15Z |
| publishDate | 2023-12-01 |
| publisher | Instituto Nacional de Salud |
| record_format | Article |
| series | Biomédica: revista del Instituto Nacional de Salud |
| spelling | doaj.art-4761690ecf454ba39933e2b0750c5da62024-01-11T19:41:04ZengInstituto Nacional de SaludBiomédica: revista del Instituto Nacional de Salud0120-41572590-73792023-12-0143Sp. 3212910.7705/biomedica.70578512Frailty syndrome and end-stage kidney disease outcomes at a Latin American dialysis centerLuis David Moreno0Carlos Eduardo Ruiz1Juan Carlos Urrego2Miguel Oswaldo Cadena3Silvia José Maldonado4Daniel Andrés Niño5Andrea Maldonado6Departamento de Medicina Interna, Hospital Universitario de Santander, Bucaramanga, ColombiaDepartamento de Medicina Interna, Hospital Universitario de Santander, Bucaramanga, ColombiaDepartamento de Medicina Interna, Hospital Universitario de Santander, Bucaramanga, ColombiaDepartamento de Medicina Interna, Hospital Universitario de Santander, Bucaramanga, ColombiaFacultad de Medicina, Universidad Industrial de Santander, Bucaramanga, ColombiaFacultad de Medicina, Universidad Industrial de Santander, Bucaramanga, ColombiaFacultad de Medicina, Universidad Industrial de Santander, Bucaramanga, ColombiaIntroduction. Frailty syndrome generates a high risk of adverse outcomes and mortality, and its prevalence is elevated in patients with end-stage kidney disease. Few studies have reported the prevalence and outcomes of frailty in populations from less developed countries. Objective. To identify the clinical outcomes and factors associated with the frailty syndrome in patients with stage five chronic kidney disease who started renal replacement therapy – both hemodialysis and peritoneal dialysis– in a dialysis center in Bucaramanga, Colombia. Materials and methods. This was a prospective study of patients with end-stage kidney disease who initiated dialysis at a center in Colombia and had a twelve-month follow-up. Results. The overall frailty prevalence was 50.47% and two out of three patients older than 65 years had the syndrome. We found significantly higher followup mortality among patients with frailty: odds ratio of 2.95 (CI: 1.07- 8.13; p=0.036) in unadjusted analysis. Conclusions. Literature shows that compared to developed nations, Latin American adults are facing a higher prevalence of chronic diseases, and frailty syndrome is raising. In this study, according to the FRAIL scale, having a frailty syndrome predicts a higher mortality; hypoalbuminemia and low creatinine levels at the beginning of dialysis could act as predictors of its diagnosis.https://revistabiomedica.org/index.php/biomedica/article/view/7057kidney diseasesfraildialysisrenal replacement therapy |
| spellingShingle | Luis David Moreno Carlos Eduardo Ruiz Juan Carlos Urrego Miguel Oswaldo Cadena Silvia José Maldonado Daniel Andrés Niño Andrea Maldonado Frailty syndrome and end-stage kidney disease outcomes at a Latin American dialysis center Biomédica: revista del Instituto Nacional de Salud kidney diseases frail dialysis renal replacement therapy |
| title | Frailty syndrome and end-stage kidney disease outcomes at a Latin American dialysis center |
| title_full | Frailty syndrome and end-stage kidney disease outcomes at a Latin American dialysis center |
| title_fullStr | Frailty syndrome and end-stage kidney disease outcomes at a Latin American dialysis center |
| title_full_unstemmed | Frailty syndrome and end-stage kidney disease outcomes at a Latin American dialysis center |
| title_short | Frailty syndrome and end-stage kidney disease outcomes at a Latin American dialysis center |
| title_sort | frailty syndrome and end stage kidney disease outcomes at a latin american dialysis center |
| topic | kidney diseases frail dialysis renal replacement therapy |
| url | https://revistabiomedica.org/index.php/biomedica/article/view/7057 |
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