Emerging SARS-CoV-2 variants: Why, how, and what's next?
The emergence of the SARS-CoV-2 Omicron variant poses a striking threat to human society. More than 30 mutations in the Spike protein of the Omicron variant severely compromised the protective immunity elicited by either vaccination or prior infection. The persistent viral evolutionary trajectory ge...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Cell Insight |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892722000268 |
| _version_ | 1828138919803224064 |
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| author | Yu Chen Qianyun Liu Li Zhou You Zhou Huan Yan Ke Lan |
| author_facet | Yu Chen Qianyun Liu Li Zhou You Zhou Huan Yan Ke Lan |
| author_sort | Yu Chen |
| collection | DOAJ |
| description | The emergence of the SARS-CoV-2 Omicron variant poses a striking threat to human society. More than 30 mutations in the Spike protein of the Omicron variant severely compromised the protective immunity elicited by either vaccination or prior infection. The persistent viral evolutionary trajectory generates Omicron-associated lineages, such as BA.1 and BA.2. Moreover, the virus recombination upon Delta and Omicron co-infections has been reported lately, although the impact remains to be assessed. This minireview summarizes the characteristics, evolution and mutation control, and immune evasion mechanisms of SARS-CoV-2 variants, which will be helpful for the in-depth understanding of the SARS-CoV-2 variants and policy-making related to COVID-19 pandemic control. |
| first_indexed | 2024-04-11T18:44:03Z |
| format | Article |
| id | doaj.art-47617474f7294154bf6f7c4f49f975b1 |
| institution | Directory Open Access Journal |
| issn | 2772-8927 |
| language | English |
| last_indexed | 2024-04-11T18:44:03Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj.art-47617474f7294154bf6f7c4f49f975b12022-12-22T04:08:53ZengElsevierCell Insight2772-89272022-06-0113100029Emerging SARS-CoV-2 variants: Why, how, and what's next?Yu Chen0Qianyun Liu1Li Zhou2You Zhou3Huan Yan4Ke Lan5State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, 430072, China; Corresponding author. State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Luojia Mountain, Wuchang District, Wuhan, 430072, China.State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, 430072, ChinaState Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, 430072, ChinaSystems Immunity University Research Institute and Division of Infection and Immunity, Cardiff University, Cardiff, UKState Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, 430072, ChinaState Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, 430072, China; Department of Infectious Diseases, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China; Corresponding author. State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Luojia Mountain, Wuchang District, Wuhan, 430072, China.The emergence of the SARS-CoV-2 Omicron variant poses a striking threat to human society. More than 30 mutations in the Spike protein of the Omicron variant severely compromised the protective immunity elicited by either vaccination or prior infection. The persistent viral evolutionary trajectory generates Omicron-associated lineages, such as BA.1 and BA.2. Moreover, the virus recombination upon Delta and Omicron co-infections has been reported lately, although the impact remains to be assessed. This minireview summarizes the characteristics, evolution and mutation control, and immune evasion mechanisms of SARS-CoV-2 variants, which will be helpful for the in-depth understanding of the SARS-CoV-2 variants and policy-making related to COVID-19 pandemic control.http://www.sciencedirect.com/science/article/pii/S2772892722000268SARS-CoV-2 variantsMutation rateOmicronDeltacronMutations in the Spike |
| spellingShingle | Yu Chen Qianyun Liu Li Zhou You Zhou Huan Yan Ke Lan Emerging SARS-CoV-2 variants: Why, how, and what's next? Cell Insight SARS-CoV-2 variants Mutation rate Omicron Deltacron Mutations in the Spike |
| title | Emerging SARS-CoV-2 variants: Why, how, and what's next? |
| title_full | Emerging SARS-CoV-2 variants: Why, how, and what's next? |
| title_fullStr | Emerging SARS-CoV-2 variants: Why, how, and what's next? |
| title_full_unstemmed | Emerging SARS-CoV-2 variants: Why, how, and what's next? |
| title_short | Emerging SARS-CoV-2 variants: Why, how, and what's next? |
| title_sort | emerging sars cov 2 variants why how and what s next |
| topic | SARS-CoV-2 variants Mutation rate Omicron Deltacron Mutations in the Spike |
| url | http://www.sciencedirect.com/science/article/pii/S2772892722000268 |
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