Complete response to FOLFOX4 therapy in a patient with advanced urothelial cancer: a case report
<p>Abstract</p> <p>No standard has been established for salvage therapy in gemcitabine refractory advanced urothelial cancer. We report the complete response to FOLFOX4 therapy of a metastatic urothelial cancer patient, for whom adjuvant gemcitabine plus cisplatin combination chemo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-01-01
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| Series: | Journal of Hematology & Oncology |
| Online Access: | http://www.jhoonline.org/content/3/1/4 |
| _version_ | 1818483003435778048 |
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| author | Koh Eun Park Seong Kim Chan Kim Hyun Kim Se Seo Yu Hong Dae |
| author_facet | Koh Eun Park Seong Kim Chan Kim Hyun Kim Se Seo Yu Hong Dae |
| author_sort | Koh Eun |
| collection | DOAJ |
| description | <p>Abstract</p> <p>No standard has been established for salvage therapy in gemcitabine refractory advanced urothelial cancer. We report the complete response to FOLFOX4 therapy of a metastatic urothelial cancer patient, for whom adjuvant gemcitabine plus cisplatin combination chemotherapy had failed. A 54-year-old male patient with urothelial cancer (transitional cell carcinoma) in the right kidney underwent three rounds of adjuvant gemcitabine-cisplatin chemotherapy after extensive radical nephrectomy. However, he had new liver, lung metastases and synchronous two separate primary colon cancer. The lung metastasis lesion was confirmed as a metastatic urothelial cancer via percutaneous transthoracic needle biopsy (PTNB). Liver and lung metastasis lesions disappeared after the 4th cycle of FOLFOX4 chemotherapy. In addition, colon cancer also disappeared after the 8th cycle of FOLFOX4 chemotherapy. The patient was still showing a complete response after 4 months. Clinical trials using the FOLFOX regimen as salvage therapy for gemcitabine-refractory advanced urothelial cancer are warranted.</p> |
| first_indexed | 2024-12-10T11:54:33Z |
| format | Article |
| id | doaj.art-47620359e1a04b7995f60eebf18cf462 |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-10T11:54:33Z |
| publishDate | 2010-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-47620359e1a04b7995f60eebf18cf4622022-12-22T01:49:49ZengBMCJournal of Hematology & Oncology1756-87222010-01-0131410.1186/1756-8722-3-4Complete response to FOLFOX4 therapy in a patient with advanced urothelial cancer: a case reportKoh EunPark SeongKim ChanKim HyunKim SeSeo YuHong Dae<p>Abstract</p> <p>No standard has been established for salvage therapy in gemcitabine refractory advanced urothelial cancer. We report the complete response to FOLFOX4 therapy of a metastatic urothelial cancer patient, for whom adjuvant gemcitabine plus cisplatin combination chemotherapy had failed. A 54-year-old male patient with urothelial cancer (transitional cell carcinoma) in the right kidney underwent three rounds of adjuvant gemcitabine-cisplatin chemotherapy after extensive radical nephrectomy. However, he had new liver, lung metastases and synchronous two separate primary colon cancer. The lung metastasis lesion was confirmed as a metastatic urothelial cancer via percutaneous transthoracic needle biopsy (PTNB). Liver and lung metastasis lesions disappeared after the 4th cycle of FOLFOX4 chemotherapy. In addition, colon cancer also disappeared after the 8th cycle of FOLFOX4 chemotherapy. The patient was still showing a complete response after 4 months. Clinical trials using the FOLFOX regimen as salvage therapy for gemcitabine-refractory advanced urothelial cancer are warranted.</p>http://www.jhoonline.org/content/3/1/4 |
| spellingShingle | Koh Eun Park Seong Kim Chan Kim Hyun Kim Se Seo Yu Hong Dae Complete response to FOLFOX4 therapy in a patient with advanced urothelial cancer: a case report Journal of Hematology & Oncology |
| title | Complete response to FOLFOX4 therapy in a patient with advanced urothelial cancer: a case report |
| title_full | Complete response to FOLFOX4 therapy in a patient with advanced urothelial cancer: a case report |
| title_fullStr | Complete response to FOLFOX4 therapy in a patient with advanced urothelial cancer: a case report |
| title_full_unstemmed | Complete response to FOLFOX4 therapy in a patient with advanced urothelial cancer: a case report |
| title_short | Complete response to FOLFOX4 therapy in a patient with advanced urothelial cancer: a case report |
| title_sort | complete response to folfox4 therapy in a patient with advanced urothelial cancer a case report |
| url | http://www.jhoonline.org/content/3/1/4 |
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