Significance of E47 and LOXL2 Expressions in Esophageal Squamous Cell Carcinoma Tissues
Objective To investigate the relationship of E47, lysyl oxidase like2 protein(LOXL2) expressions with clinicopathologic parameters of esophageal squamous cell carcinoma(ESCC) patients. Methods The mRNA and protein levels of E47 and LOXL2 in ESCC and adjacent tissues were detected by qRT-PCR and immu...
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Magazine House of Cancer Research on Prevention and Treatment
2018-09-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2018.18.0137.htm |
| _version_ | 1818280022235938816 |
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| author | MA Hong ZHANG Yanping HOU Minjie LI Jinyu ZHU Yajie DILIHUMAER·Aihaiti GUO Qiong MA Yuqing |
| author_facet | MA Hong ZHANG Yanping HOU Minjie LI Jinyu ZHU Yajie DILIHUMAER·Aihaiti GUO Qiong MA Yuqing |
| author_sort | MA Hong |
| collection | DOAJ |
| description | Objective To investigate the relationship of E47, lysyl oxidase like2 protein(LOXL2) expressions with clinicopathologic parameters of esophageal squamous cell carcinoma(ESCC) patients. Methods The mRNA and protein levels of E47 and LOXL2 in ESCC and adjacent tissues were detected by qRT-PCR and immunohistochemistry method, and their correlation with the clinicopathologic parameters were analyzed. Results The expressions of E47 and LOXL2 mRNA in ESCC tissues were significantly higher than those in adjacent normal tissues (all P < 0.05). The positive expressions of E47 and LOXL2 proteins in ESCC were higher than those in adjacent tissues (all P < 0.05). The expression of E47 protein was closely correlated with invasion depth. The expression of LOXL2 protein was both significantly correlated with the level of histological differentiation and lymphatic metastasis (P < 0.05). E47 protein expression was positively correlated with LOXL2 expression (r=0.582, P < 0.05). Conclusion The mRNA and protein levels of E47 and LOXL-2 are highly expressed in ESCC tissues, and significantly correlated with clinicopathologic characteristics. High expressions of E47 and LOXL2 may promote the invasion and metastasis of ESCC, and they are expected to be the potential biomarkers for the prognosis. |
| first_indexed | 2024-12-12T23:42:37Z |
| format | Article |
| id | doaj.art-4762350904fc48a490771984b9feb832 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-12T23:42:37Z |
| publishDate | 2018-09-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-4762350904fc48a490771984b9feb8322022-12-22T00:07:02ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782018-09-0145964765110.3971/j.issn.1000-8578.2018.18.01378578.2018.18.0137Significance of E47 and LOXL2 Expressions in Esophageal Squamous Cell Carcinoma TissuesMA Hong0ZHANG Yanping1HOU Minjie2LI Jinyu3ZHU Yajie4DILIHUMAER·Aihaiti5GUO Qiong6MA Yuqing7Department of Pathology, Basic Medical College, Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Pathology, Basic Medical College, Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Pathology, Basic Medical College, Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Pathology, Basic Medical College, Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Pathology, Basic Medical College, Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Pathology, Basic Medical College, Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Histology and Embryology, Basic Medical College, Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, ChinaObjective To investigate the relationship of E47, lysyl oxidase like2 protein(LOXL2) expressions with clinicopathologic parameters of esophageal squamous cell carcinoma(ESCC) patients. Methods The mRNA and protein levels of E47 and LOXL2 in ESCC and adjacent tissues were detected by qRT-PCR and immunohistochemistry method, and their correlation with the clinicopathologic parameters were analyzed. Results The expressions of E47 and LOXL2 mRNA in ESCC tissues were significantly higher than those in adjacent normal tissues (all P < 0.05). The positive expressions of E47 and LOXL2 proteins in ESCC were higher than those in adjacent tissues (all P < 0.05). The expression of E47 protein was closely correlated with invasion depth. The expression of LOXL2 protein was both significantly correlated with the level of histological differentiation and lymphatic metastasis (P < 0.05). E47 protein expression was positively correlated with LOXL2 expression (r=0.582, P < 0.05). Conclusion The mRNA and protein levels of E47 and LOXL-2 are highly expressed in ESCC tissues, and significantly correlated with clinicopathologic characteristics. High expressions of E47 and LOXL2 may promote the invasion and metastasis of ESCC, and they are expected to be the potential biomarkers for the prognosis.http://html.rhhz.net/ZLFZYJ/html/8578.2018.18.0137.htmesophageal squamous cell carcinomae47loxl2emt |
| spellingShingle | MA Hong ZHANG Yanping HOU Minjie LI Jinyu ZHU Yajie DILIHUMAER·Aihaiti GUO Qiong MA Yuqing Significance of E47 and LOXL2 Expressions in Esophageal Squamous Cell Carcinoma Tissues Zhongliu Fangzhi Yanjiu esophageal squamous cell carcinoma e47 loxl2 emt |
| title | Significance of E47 and LOXL2 Expressions in Esophageal Squamous Cell Carcinoma Tissues |
| title_full | Significance of E47 and LOXL2 Expressions in Esophageal Squamous Cell Carcinoma Tissues |
| title_fullStr | Significance of E47 and LOXL2 Expressions in Esophageal Squamous Cell Carcinoma Tissues |
| title_full_unstemmed | Significance of E47 and LOXL2 Expressions in Esophageal Squamous Cell Carcinoma Tissues |
| title_short | Significance of E47 and LOXL2 Expressions in Esophageal Squamous Cell Carcinoma Tissues |
| title_sort | significance of e47 and loxl2 expressions in esophageal squamous cell carcinoma tissues |
| topic | esophageal squamous cell carcinoma e47 loxl2 emt |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2018.18.0137.htm |
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