Association of Maternal Vitamin C Status with Gestational Diabetes Mellitus
Background: The role of antioxidants in the etiology of gestational diabetes mellitus (GDM) has been given limited attention. Vitamin C is a nutrient with radical quenching property and has been claimed to influence glucose tolerance. Aim: To study the association between vitamin C status (diet...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Krishna Institute of Medical Sciences University
2015-01-01
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| Series: | Journal of Krishna Institute of Medical Sciences University |
| Subjects: | |
| Online Access: | http://jkimsu.com/jkimsu-vol4no3/JKIMSU,%20Vol.%204,%20No.%203,%20July-Sept%202015%20Page%2066-73.pdf |
| Summary: | Background: The role of antioxidants in the etiology of
gestational diabetes mellitus (GDM) has been given
limited attention. Vitamin C is a nutrient with radical
quenching property and has been claimed to influence
glucose tolerance. Aim: To study the association
between vitamin C status (dietary intake and plasma
concentrations) and GDM. Material and Methods:
Using a case-control design with 1:3 ratio we examined
42 pregnant women with GDM and 158 normal glucose
tolerant (NGT) gestational age-matched healthy
pregnant women at an average of 26 weeks of gestation.
Maternal vitamin C intake was determined using
detailed semi food frequency questionnaire (SFFQ) and
24 hour diet recall. Plasma vitamin C was determined
using a spectrophotometric method in non-fasting
samples. GDM was diagnosed by 75 gm oral glucose
tolerance test (OGTT) using International Association
for Diabetes in Pregnancy Study Group (IADPSG)
criteria (fasting ≥92mg%, 1hour ≥180mg%, 2 hour
≥153mg %). Results: GDM women had lower median
intake of vitamin C (35.0 mg/day vs. 66.7; p<0.001)
and lower median plasma vitamin C concentration
(45.9 µmol/L vs. 95.2; p<0.001) compared to NGT
women. Plasma vitamin C concentration was inversely
related to fasting, 1 hour and 2 hour post glucose plasma
glucose concentrations (p<0.001). The associations
remained significant after adjustment for age, income,
pre-pregnancy BMI, and stress. Conclusion: Our
findings suggest that low vitamin C intake as well as
low plasma vitamin C concentration is associated with
GDM. This association needs to be tested in a large
prospective study and subsequently in a clinical trial |
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| ISSN: | 2231-4261 2231-4261 |