B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and show that disrupting B1-B1 interactions precludes...
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Bibliographic Details
| Main Authors: |
Yuwen Li,
Xiaodan Ma,
Zhiming Chen,
Haiyan Wu,
Pengran Wang,
Wenyu Wu,
Nuo Cheng,
Longhui Zeng,
Hao Zhang,
Xun Cai,
Sai-Juan Chen,
Zhu Chen,
Guoyu Meng |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2019-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-11746-0
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