Vasoregulating activity of the endothelium and pulmonary hypertension
Aim. To examine vasoregulating endothelial activity in patients with bronchial asthma (BA) with pulmonary hypertension (PH) and free of PH. Material and methods. A total of 62 BA patients aged between 19 and 52 entered the trial. They were divided into two groups: 44 with PH and 18 free of it. The...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2004-12-01
|
| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/29946 |
| Summary: | Aim. To examine vasoregulating endothelial activity in patients with bronchial asthma (BA) with pulmonary
hypertension (PH) and free of PH.
Material and methods. A total of 62 BA patients aged between 19 and 52 entered the trial. They were
divided into two groups: 44 with PH and 18 free of it. The control group consisted of 35 healthy sub-
jects. Vasoregulating activity of the vascular wall was studied by tests with reactive hyperemia (endothelium-dependent
dilation) and 0.05 mg nitroglycerin (endothetium-dependent dilation).
Results. It was found that BA patients with PH have a dilated brachial artery, abnormal endotheliumdependent
vasodilation of the brachial artery. The artery is low sensitive to shift tension. These changes
in functional activity of brachial artery endothelium in BA patients with PH are associated with impaired
pulmonary hemodynamics, right ventricular diastolic dunction. |
|---|---|
| ISSN: | 0040-3660 2309-5342 |