Vascular Endothelial Growth Factor Levels in Gingival Crevicular Fluid Before and after Periodontal Therapy
Introduction: Of the various cytokines and growth factors regulating angiogenesis, the most potent agent acting on vascular endothelium is vascular endothelial growth factor(VEGF). The present study aims to access VEGF concentration in periodontal diseases and the effect of periodontal therapy o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5163/8450_CE(RA1)_F(T)_PF1(PU_Sh)_PFA(Sh)_PF2(PAG).pdf |
| Summary: | Introduction: Of the various cytokines and growth factors
regulating angiogenesis, the most potent agent acting on vascular
endothelium is vascular endothelial growth factor(VEGF). The
present study aims to access VEGF concentration in periodontal
diseases and the effect of periodontal therapy on its concentration
in gingival crevicular fluid (GCF).
Materials and Methods: Ninety five subjects (47 females and
48 males) 25- 47 y of age were divided into healthy (group-1),
gingivitis (group-2), and periodontitis (group-3). GCF samples
were collected using micro-capillary pipettes & were transferred
immediately to plastic vials and stored at -70˚C until the time of
the assay. The concentration of VEGF was determined using
commercially available ELISA kit.
Results: The mean VEGF concentration was highest in
periodontitis patients (Group 3) (88.08±8.04pg/ml), with lowest
in healthy patients (Group 1). VEGF levels reduced significantly
after therapy in Groups 2 and 3.
Conclusion: VEGF levels in GCF had a significant correlation with
both periodontal disease progression and healing after therapy. |
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| ISSN: | 2249-782X 0973-709X |