Vascular Endothelial Growth Factor Levels in Gingival Crevicular Fluid Before and after Periodontal Therapy
Introduction: Of the various cytokines and growth factors regulating angiogenesis, the most potent agent acting on vascular endothelium is vascular endothelial growth factor(VEGF). The present study aims to access VEGF concentration in periodontal diseases and the effect of periodontal therapy o...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-11-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5163/8450_CE(RA1)_F(T)_PF1(PU_Sh)_PFA(Sh)_PF2(PAG).pdf |
| _version_ | 1818791674419085312 |
|---|---|
| author | Padma R. Annaji Sreedhara Indeevar P. Indranil Sarkar Chetan S Kumar |
| author_facet | Padma R. Annaji Sreedhara Indeevar P. Indranil Sarkar Chetan S Kumar |
| author_sort | Padma R. |
| collection | DOAJ |
| description | Introduction: Of the various cytokines and growth factors
regulating angiogenesis, the most potent agent acting on vascular
endothelium is vascular endothelial growth factor(VEGF). The
present study aims to access VEGF concentration in periodontal
diseases and the effect of periodontal therapy on its concentration
in gingival crevicular fluid (GCF).
Materials and Methods: Ninety five subjects (47 females and
48 males) 25- 47 y of age were divided into healthy (group-1),
gingivitis (group-2), and periodontitis (group-3). GCF samples
were collected using micro-capillary pipettes & were transferred
immediately to plastic vials and stored at -70˚C until the time of
the assay. The concentration of VEGF was determined using
commercially available ELISA kit.
Results: The mean VEGF concentration was highest in
periodontitis patients (Group 3) (88.08±8.04pg/ml), with lowest
in healthy patients (Group 1). VEGF levels reduced significantly
after therapy in Groups 2 and 3.
Conclusion: VEGF levels in GCF had a significant correlation with
both periodontal disease progression and healing after therapy. |
| first_indexed | 2024-12-18T15:15:06Z |
| format | Article |
| id | doaj.art-476648d36f2248eeab509a1c965a3807 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-18T15:15:06Z |
| publishDate | 2014-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-476648d36f2248eeab509a1c965a38072022-12-21T21:03:32ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-11-01811ZC75ZC7910.7860/JCDR/2014/8450.5163Vascular Endothelial Growth Factor Levels in Gingival Crevicular Fluid Before and after Periodontal TherapyPadma R.0Annaji Sreedhara1Indeevar P.2Indranil Sarkar3Chetan S Kumar4Head of the Department, Department of Periodontics, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.Reader, Department of Periodontics, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.Senior Lecturer, Department of Periodontics, St. Joseph Dental College, Eluru, Andhra Pradesh, India.Post Graduate Student, Department of Periodontics, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.Reader, Department of Orthodontics, St. Joseph Dental College, Eluru, Andhra Pradesh, India.Introduction: Of the various cytokines and growth factors regulating angiogenesis, the most potent agent acting on vascular endothelium is vascular endothelial growth factor(VEGF). The present study aims to access VEGF concentration in periodontal diseases and the effect of periodontal therapy on its concentration in gingival crevicular fluid (GCF). Materials and Methods: Ninety five subjects (47 females and 48 males) 25- 47 y of age were divided into healthy (group-1), gingivitis (group-2), and periodontitis (group-3). GCF samples were collected using micro-capillary pipettes & were transferred immediately to plastic vials and stored at -70˚C until the time of the assay. The concentration of VEGF was determined using commercially available ELISA kit. Results: The mean VEGF concentration was highest in periodontitis patients (Group 3) (88.08±8.04pg/ml), with lowest in healthy patients (Group 1). VEGF levels reduced significantly after therapy in Groups 2 and 3. Conclusion: VEGF levels in GCF had a significant correlation with both periodontal disease progression and healing after therapy.https://jcdr.net/articles/PDF/5163/8450_CE(RA1)_F(T)_PF1(PU_Sh)_PFA(Sh)_PF2(PAG).pdfangiogenesisgingival crevicular fluidperiodontitisvascular endothelial growth factor |
| spellingShingle | Padma R. Annaji Sreedhara Indeevar P. Indranil Sarkar Chetan S Kumar Vascular Endothelial Growth Factor Levels in Gingival Crevicular Fluid Before and after Periodontal Therapy Journal of Clinical and Diagnostic Research angiogenesis gingival crevicular fluid periodontitis vascular endothelial growth factor |
| title | Vascular Endothelial Growth Factor Levels in Gingival Crevicular Fluid Before and after Periodontal Therapy |
| title_full | Vascular Endothelial Growth Factor Levels in Gingival Crevicular Fluid Before and after Periodontal Therapy |
| title_fullStr | Vascular Endothelial Growth Factor Levels in Gingival Crevicular Fluid Before and after Periodontal Therapy |
| title_full_unstemmed | Vascular Endothelial Growth Factor Levels in Gingival Crevicular Fluid Before and after Periodontal Therapy |
| title_short | Vascular Endothelial Growth Factor Levels in Gingival Crevicular Fluid Before and after Periodontal Therapy |
| title_sort | vascular endothelial growth factor levels in gingival crevicular fluid before and after periodontal therapy |
| topic | angiogenesis gingival crevicular fluid periodontitis vascular endothelial growth factor |
| url | https://jcdr.net/articles/PDF/5163/8450_CE(RA1)_F(T)_PF1(PU_Sh)_PFA(Sh)_PF2(PAG).pdf |
| work_keys_str_mv | AT padmar vascularendothelialgrowthfactorlevelsingingivalcrevicularfluidbeforeandafterperiodontaltherapy AT annajisreedhara vascularendothelialgrowthfactorlevelsingingivalcrevicularfluidbeforeandafterperiodontaltherapy AT indeevarp vascularendothelialgrowthfactorlevelsingingivalcrevicularfluidbeforeandafterperiodontaltherapy AT indranilsarkar vascularendothelialgrowthfactorlevelsingingivalcrevicularfluidbeforeandafterperiodontaltherapy AT chetanskumar vascularendothelialgrowthfactorlevelsingingivalcrevicularfluidbeforeandafterperiodontaltherapy |