Feasibility and toxicity of hematopoietic stem cell transplant in multiple sclerosis
Multiple sclerosis is a debilitating disease of the central nervous system. It affects people of all ages but is more prevalent among 20-40 year olds. Patients with MS can be presented with potentially any neurological symptom depending on the location of the lesion. A quarter of patients with MS su...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2017-07-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_9000_655ba114f049f9d1cc7105ad57c81e21.pdf |
| _version_ | 1818234127713828864 |
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| author | Thomas Low Tat Kuan Farahnaz Amini Marjan Seghayat |
| author_facet | Thomas Low Tat Kuan Farahnaz Amini Marjan Seghayat |
| author_sort | Thomas Low Tat Kuan |
| collection | DOAJ |
| description | Multiple sclerosis is a debilitating disease of the central nervous system. It affects people of all ages but is more prevalent among 20-40 year olds. Patients with MS can be presented with potentially any neurological symptom depending on the location of the lesion. A quarter of patients with MS suffer from bilateral lower limb spasticity among other symptoms. These devastating effects can be detrimental to the patient's quality of life. Hematopoietic stem cells (HSCs) have been used as a treatment for MS over the past 2 decades but their safety and efficacy has are undetermined. The objective of this study is to evaluate the feasibility and toxicity of autologous HSCs transplantation in MS. A literature search was done from 1997 to 2016 using different keywords. A total of 9 articles, which met the inclusion and exclusion criteria, were included in this review. The type of conditioning regimen and technique of stem cell mobilization are summarized and compared in this study. All studies reported high-dose immunosuppressive therapy with autologous HSCs transplantation being an effective treatment option for severe cases of multiple sclerosis. Fever, sepsis, and immunosuppression side effects were the most observed adverse effects that were reported in the selected studies. HSCs is a feasible treatment for patients with MS; nevertheless the safety is still a concern due to chemo toxicity. |
| first_indexed | 2024-12-12T11:33:08Z |
| format | Article |
| id | doaj.art-4768ead4df6c48339ba29c87decedab9 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-12T11:33:08Z |
| publishDate | 2017-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-4768ead4df6c48339ba29c87decedab92022-12-22T00:25:44ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742017-07-0120772973810.22038/ijbms.2017.90009000Feasibility and toxicity of hematopoietic stem cell transplant in multiple sclerosisThomas Low Tat Kuan0Farahnaz Amini1Marjan Seghayat2School of Healthy Aging, Medical Aesthetics and Regenerative Medicine, Faculty of Medicine and Health Science, UCSI University, Kuala Lumpur, MalaysiaSchool of Healthy Aging, Medical Aesthetics and Regenerative Medicine, Faculty of Medicine and Health Science, UCSI University, Kuala Lumpur, MalaysiaSchool of Healthy Aging, Medical Aesthetics and Regenerative Medicine, Faculty of Medicine and Health Science, UCSI University, Kuala Lumpur, MalaysiaMultiple sclerosis is a debilitating disease of the central nervous system. It affects people of all ages but is more prevalent among 20-40 year olds. Patients with MS can be presented with potentially any neurological symptom depending on the location of the lesion. A quarter of patients with MS suffer from bilateral lower limb spasticity among other symptoms. These devastating effects can be detrimental to the patient's quality of life. Hematopoietic stem cells (HSCs) have been used as a treatment for MS over the past 2 decades but their safety and efficacy has are undetermined. The objective of this study is to evaluate the feasibility and toxicity of autologous HSCs transplantation in MS. A literature search was done from 1997 to 2016 using different keywords. A total of 9 articles, which met the inclusion and exclusion criteria, were included in this review. The type of conditioning regimen and technique of stem cell mobilization are summarized and compared in this study. All studies reported high-dose immunosuppressive therapy with autologous HSCs transplantation being an effective treatment option for severe cases of multiple sclerosis. Fever, sepsis, and immunosuppression side effects were the most observed adverse effects that were reported in the selected studies. HSCs is a feasible treatment for patients with MS; nevertheless the safety is still a concern due to chemo toxicity.http://ijbms.mums.ac.ir/article_9000_655ba114f049f9d1cc7105ad57c81e21.pdfEfficacyFeasibilityHematopoietic stem cellMultiple SclerosisTransplantationToxicity |
| spellingShingle | Thomas Low Tat Kuan Farahnaz Amini Marjan Seghayat Feasibility and toxicity of hematopoietic stem cell transplant in multiple sclerosis Iranian Journal of Basic Medical Sciences Efficacy Feasibility Hematopoietic stem cell Multiple Sclerosis Transplantation Toxicity |
| title | Feasibility and toxicity of hematopoietic stem cell transplant in multiple sclerosis |
| title_full | Feasibility and toxicity of hematopoietic stem cell transplant in multiple sclerosis |
| title_fullStr | Feasibility and toxicity of hematopoietic stem cell transplant in multiple sclerosis |
| title_full_unstemmed | Feasibility and toxicity of hematopoietic stem cell transplant in multiple sclerosis |
| title_short | Feasibility and toxicity of hematopoietic stem cell transplant in multiple sclerosis |
| title_sort | feasibility and toxicity of hematopoietic stem cell transplant in multiple sclerosis |
| topic | Efficacy Feasibility Hematopoietic stem cell Multiple Sclerosis Transplantation Toxicity |
| url | http://ijbms.mums.ac.ir/article_9000_655ba114f049f9d1cc7105ad57c81e21.pdf |
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