Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system
Abstract Crosstalk between central nervous system (CNS) and systemic responses is important in many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy, etc. Accumulating evidence suggest that signals for central-systemic crosstalk may utilize glymphatic and lymphat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-05911-5 |
| _version_ | 1797273589327593472 |
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| author | Ester Licastro Giuseppe Pignataro Jeffrey J. Iliff Yanxiao Xiang Eng H. Lo Kazuhide Hayakawa Elga Esposito |
| author_facet | Ester Licastro Giuseppe Pignataro Jeffrey J. Iliff Yanxiao Xiang Eng H. Lo Kazuhide Hayakawa Elga Esposito |
| author_sort | Ester Licastro |
| collection | DOAJ |
| description | Abstract Crosstalk between central nervous system (CNS) and systemic responses is important in many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy, etc. Accumulating evidence suggest that signals for central-systemic crosstalk may utilize glymphatic and lymphatic pathways. The glymphatic system is functionally connected to the meningeal lymphatic system, and together these pathways may be involved in the distribution of soluble proteins and clearance of metabolites and waste products from the CNS. Lymphatic vessels in the dura and meninges transport cerebrospinal fluid, in part collected from the glymphatic system, to the cervical lymph nodes, where solutes coming from the brain (i.e., VEGFC, oligomeric α-syn, β-amyloid) might activate a systemic inflammatory response. There is also an element of time since the immune system is strongly regulated by circadian rhythms, and both glymphatic and lymphatic dynamics have been shown to change during the day and night. Understanding the mechanisms regulating the brain-cervical lymph node (CLN) signaling and how it might be affected by diurnal or circadian rhythms is fundamental to find specific targets and timing for therapeutic interventions. |
| first_indexed | 2024-03-07T14:45:34Z |
| format | Article |
| id | doaj.art-476ac2c501e64aada3f1149795fea1be |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-07T14:45:34Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-476ac2c501e64aada3f1149795fea1be2024-03-05T19:59:27ZengNature PortfolioCommunications Biology2399-36422024-02-01711910.1038/s42003-024-05911-5Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous systemEster Licastro0Giuseppe Pignataro1Jeffrey J. Iliff2Yanxiao Xiang3Eng H. Lo4Kazuhide Hayakawa5Elga Esposito6Neuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical SchoolDivision of Pharmacology, Department of Neuroscience, School of Medicine, University “Federico II”Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science UniversityNeuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical SchoolNeuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical SchoolNeuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical SchoolNeuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical SchoolAbstract Crosstalk between central nervous system (CNS) and systemic responses is important in many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy, etc. Accumulating evidence suggest that signals for central-systemic crosstalk may utilize glymphatic and lymphatic pathways. The glymphatic system is functionally connected to the meningeal lymphatic system, and together these pathways may be involved in the distribution of soluble proteins and clearance of metabolites and waste products from the CNS. Lymphatic vessels in the dura and meninges transport cerebrospinal fluid, in part collected from the glymphatic system, to the cervical lymph nodes, where solutes coming from the brain (i.e., VEGFC, oligomeric α-syn, β-amyloid) might activate a systemic inflammatory response. There is also an element of time since the immune system is strongly regulated by circadian rhythms, and both glymphatic and lymphatic dynamics have been shown to change during the day and night. Understanding the mechanisms regulating the brain-cervical lymph node (CLN) signaling and how it might be affected by diurnal or circadian rhythms is fundamental to find specific targets and timing for therapeutic interventions.https://doi.org/10.1038/s42003-024-05911-5 |
| spellingShingle | Ester Licastro Giuseppe Pignataro Jeffrey J. Iliff Yanxiao Xiang Eng H. Lo Kazuhide Hayakawa Elga Esposito Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system Communications Biology |
| title | Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system |
| title_full | Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system |
| title_fullStr | Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system |
| title_full_unstemmed | Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system |
| title_short | Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system |
| title_sort | glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system |
| url | https://doi.org/10.1038/s42003-024-05911-5 |
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