F-Box Protein FBXW17-Mediated Proteasomal Degradation of Protein Methyltransferase PRMT6 Exaggerates CSE-Induced Lung Epithelial Inflammation and Apoptosis

F-Box Protein FBXW17-Mediated Proteasomal Degradation of Protein Methyltransferase PRMT6 Exaggerates CSE-Induced Lung Epithelial Inflammation and Apoptosis

Chronic obstructive pulmonary disease (COPD) is a chronic debilitating lung disease, characterized by progressive airway inflammation and lung structural cell death. Cigarette smoke is considered the most common risk factor of COPD pathogenesis. Understanding the molecular mechanisms of persistent i...

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Bibliographic Details
Main Authors: Tiao Li, Xue He, Lijuan Luo, Huihui Zeng, Siying Ren, Yan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
apoptosis
inflammation
cigarette smoke extract
protein arginine methyltransferase 6 (PRMT6)
FBXW17
chronic obstructive pulmonary disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.599020/full

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