GENETIC ASPECTS OF MYOCARDIAL INFARCTION: PROBLEMS AND PERSPECTIVES
The role of hereditary factors in the development of coronary heart disease and myocardial infarction is known, but the underlying pathogenetic mechanisms remain understudied. Multiple studies of candidate genes (those coding protein synthesis, participating in atherosclerosis pathogenesis, or regul...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2012-02-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1184 |
| _version_ | 1797857151339724800 |
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| author | P. A. Shesternya V. A. Shulman S. Yu. Nikulina |
| author_facet | P. A. Shesternya V. A. Shulman S. Yu. Nikulina |
| author_sort | P. A. Shesternya |
| collection | DOAJ |
| description | The role of hereditary factors in the development of coronary heart disease and myocardial infarction is known, but the underlying pathogenetic mechanisms remain understudied. Multiple studies of candidate genes (those coding protein synthesis, participating in atherosclerosis pathogenesis, or regulating hemostasis and inflammation) have not been particularly successful. The main problem of these studies has been a very low level of reproducibility of the results obtained. By contrast, whole-genome association studies have provided new perspectives in this research area. This review discusses the modern relevant evidence and new directions for future research. |
| first_indexed | 2024-04-09T20:51:54Z |
| format | Article |
| id | doaj.art-476c0f59634d40339277fdb5d7b40d8e |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:51:54Z |
| publishDate | 2012-02-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-476c0f59634d40339277fdb5d7b40d8e2023-03-29T21:23:18Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202012-02-010149988GENETIC ASPECTS OF MYOCARDIAL INFARCTION: PROBLEMS AND PERSPECTIVESP. A. Shesternya0V. A. Shulman1S. Yu. Nikulina2Prof. V. F. Voyno-Yasenetskyi Krasnoyarsk State Medical University, Krasnoyarsk, RussiaProf. V. F. Voyno-Yasenetskyi Krasnoyarsk State Medical University, Krasnoyarsk, RussiaProf. V. F. Voyno-Yasenetskyi Krasnoyarsk State Medical University, Krasnoyarsk, RussiaThe role of hereditary factors in the development of coronary heart disease and myocardial infarction is known, but the underlying pathogenetic mechanisms remain understudied. Multiple studies of candidate genes (those coding protein synthesis, participating in atherosclerosis pathogenesis, or regulating hemostasis and inflammation) have not been particularly successful. The main problem of these studies has been a very low level of reproducibility of the results obtained. By contrast, whole-genome association studies have provided new perspectives in this research area. This review discusses the modern relevant evidence and new directions for future research.https://russjcardiol.elpub.ru/jour/article/view/1184инфаркт миокардагенетикапредикторыполиморфизмы |
| spellingShingle | P. A. Shesternya V. A. Shulman S. Yu. Nikulina GENETIC ASPECTS OF MYOCARDIAL INFARCTION: PROBLEMS AND PERSPECTIVES Российский кардиологический журнал инфаркт миокарда генетика предикторы полиморфизмы |
| title | GENETIC ASPECTS OF MYOCARDIAL INFARCTION: PROBLEMS AND PERSPECTIVES |
| title_full | GENETIC ASPECTS OF MYOCARDIAL INFARCTION: PROBLEMS AND PERSPECTIVES |
| title_fullStr | GENETIC ASPECTS OF MYOCARDIAL INFARCTION: PROBLEMS AND PERSPECTIVES |
| title_full_unstemmed | GENETIC ASPECTS OF MYOCARDIAL INFARCTION: PROBLEMS AND PERSPECTIVES |
| title_short | GENETIC ASPECTS OF MYOCARDIAL INFARCTION: PROBLEMS AND PERSPECTIVES |
| title_sort | genetic aspects of myocardial infarction problems and perspectives |
| topic | инфаркт миокарда генетика предикторы полиморфизмы |
| url | https://russjcardiol.elpub.ru/jour/article/view/1184 |
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