Endometrial Cancer with Sarcoidosis in Regional Lymph Nodes: A Case Report
Sarcoidosis is a chronic, multisystemic disease commonly affecting the lungs and lymphatic system and is characterized by the formation of noncaseating granulomas. Although several reports are available on cases developing both sarcoidosis and cancer metachronously, cases of simultaneous diagnosis o...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2015-10-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/440800 |
| _version_ | 1818318427170799616 |
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| author | Satoshi Tamauchi Yuji Shimomura Hiromi Hayakawa |
| author_facet | Satoshi Tamauchi Yuji Shimomura Hiromi Hayakawa |
| author_sort | Satoshi Tamauchi |
| collection | DOAJ |
| description | Sarcoidosis is a chronic, multisystemic disease commonly affecting the lungs and lymphatic system and is characterized by the formation of noncaseating granulomas. Although several reports are available on cases developing both sarcoidosis and cancer metachronously, cases of simultaneous diagnosis of these diseases have rarely been reported. A 67-year-old woman diagnosed with endometrial cancer had developed systemic lymph node swelling, including bilateral hilar, paraaortic, and a few pelvic lymph nodes, as observed on preoperative imaging. During surgery, frozen sections of a paraaortic lymph node were examined, revealing noncaseating granulomas compatible with sarcoidosis. Next, modified radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy were performed. Postoperative pathological analysis revealed endometrioid adenocarcinoma of the uterus, and no metastasis but noncaseating granulomas were detected in the resected lymph nodes. Postoperatively, we identified cutaneous sarcoidosis and uveitis in the presence of a tuberculin-negative test. On the basis of these findings, we diagnosed the patients with endometrial cancer complicated by sarcoidosis. She underwent adjuvant chemotherapy, and at the 1-year follow-up, the lymph node swelling due to sarcoidosis was stable, and no recurrence of the cancer was observed. This turned out to be a case of early endometrial cancer mimicking advanced cancer by sarcoidosis. Histological confirmation and additional examination for sarcoidosis are necessary in cancer patients suspected of sarcoidosis. |
| first_indexed | 2024-12-13T09:53:03Z |
| format | Article |
| id | doaj.art-476c373d2a4946c1908b0d9349858ea6 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-13T09:53:03Z |
| publishDate | 2015-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-476c373d2a4946c1908b0d9349858ea62022-12-21T23:51:53ZengKarger PublishersCase Reports in Oncology1662-65752015-10-018340941510.1159/000440800440800Endometrial Cancer with Sarcoidosis in Regional Lymph Nodes: A Case ReportSatoshi TamauchiYuji ShimomuraHiromi HayakawaSarcoidosis is a chronic, multisystemic disease commonly affecting the lungs and lymphatic system and is characterized by the formation of noncaseating granulomas. Although several reports are available on cases developing both sarcoidosis and cancer metachronously, cases of simultaneous diagnosis of these diseases have rarely been reported. A 67-year-old woman diagnosed with endometrial cancer had developed systemic lymph node swelling, including bilateral hilar, paraaortic, and a few pelvic lymph nodes, as observed on preoperative imaging. During surgery, frozen sections of a paraaortic lymph node were examined, revealing noncaseating granulomas compatible with sarcoidosis. Next, modified radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy were performed. Postoperative pathological analysis revealed endometrioid adenocarcinoma of the uterus, and no metastasis but noncaseating granulomas were detected in the resected lymph nodes. Postoperatively, we identified cutaneous sarcoidosis and uveitis in the presence of a tuberculin-negative test. On the basis of these findings, we diagnosed the patients with endometrial cancer complicated by sarcoidosis. She underwent adjuvant chemotherapy, and at the 1-year follow-up, the lymph node swelling due to sarcoidosis was stable, and no recurrence of the cancer was observed. This turned out to be a case of early endometrial cancer mimicking advanced cancer by sarcoidosis. Histological confirmation and additional examination for sarcoidosis are necessary in cancer patients suspected of sarcoidosis.http://www.karger.com/Article/FullText/440800Noncaseating granulomasEndometrial cancerSarcoidosis |
| spellingShingle | Satoshi Tamauchi Yuji Shimomura Hiromi Hayakawa Endometrial Cancer with Sarcoidosis in Regional Lymph Nodes: A Case Report Case Reports in Oncology Noncaseating granulomas Endometrial cancer Sarcoidosis |
| title | Endometrial Cancer with Sarcoidosis in Regional Lymph Nodes: A Case Report |
| title_full | Endometrial Cancer with Sarcoidosis in Regional Lymph Nodes: A Case Report |
| title_fullStr | Endometrial Cancer with Sarcoidosis in Regional Lymph Nodes: A Case Report |
| title_full_unstemmed | Endometrial Cancer with Sarcoidosis in Regional Lymph Nodes: A Case Report |
| title_short | Endometrial Cancer with Sarcoidosis in Regional Lymph Nodes: A Case Report |
| title_sort | endometrial cancer with sarcoidosis in regional lymph nodes a case report |
| topic | Noncaseating granulomas Endometrial cancer Sarcoidosis |
| url | http://www.karger.com/Article/FullText/440800 |
| work_keys_str_mv | AT satoshitamauchi endometrialcancerwithsarcoidosisinregionallymphnodesacasereport AT yujishimomura endometrialcancerwithsarcoidosisinregionallymphnodesacasereport AT hiromihayakawa endometrialcancerwithsarcoidosisinregionallymphnodesacasereport |