Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes
Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate immune system. Mononuclear phagocyte is an umbrella term for monocytes, macrophages, and dendritic cells. These cells play...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S104366182300083X |
| _version_ | 1797740515287891968 |
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| author | Katrin Richter Veronika Grau |
| author_facet | Katrin Richter Veronika Grau |
| author_sort | Katrin Richter |
| collection | DOAJ |
| description | Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate immune system. Mononuclear phagocyte is an umbrella term for monocytes, macrophages, and dendritic cells. These cells play pivotal roles in host defense against infection but also in numerous often debilitating diseases that are characterized by exuberant inflammation. Nicotinic acetylcholine receptors of the neuronal type dominate in these cells, and their stimulation is mainly associated with anti-inflammatory effects. Although the cholinergic modulation of mononuclear phagocytes is of eminent clinical relevance for the prevention and treatment of inflammatory diseases and neuropathic pain, we are only beginning to understand the underlying mechanisms on the molecular level. The purpose of this review is to report and critically discuss the current knowledge on signal transduction mechanisms elicited by nicotinic acetylcholine receptors in mononuclear phagocytes. |
| first_indexed | 2024-03-12T14:13:31Z |
| format | Article |
| id | doaj.art-476c599757be45b586b54cf21581f0f3 |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-12T14:13:31Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-476c599757be45b586b54cf21581f0f32023-08-21T04:19:50ZengElsevierPharmacological Research1096-11862023-05-01191106727Signaling of nicotinic acetylcholine receptors in mononuclear phagocytesKatrin Richter0Veronika Grau1Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus-Liebig-University Giessen, GermanyLaboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus-Liebig-University Giessen, Germany; German Centre for Lung Research (DZL), Giessen, Germany; Cardiopulmonary Institute (CPI), Giessen, Germany; Correspondence to: Justus-Liebig-University of Giessen, Department of General and Thoracic Surgery, Laboratory of Experimental Surgery, Feulgenstr. 10 – 12, D-35392 Giessen, Germany.Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate immune system. Mononuclear phagocyte is an umbrella term for monocytes, macrophages, and dendritic cells. These cells play pivotal roles in host defense against infection but also in numerous often debilitating diseases that are characterized by exuberant inflammation. Nicotinic acetylcholine receptors of the neuronal type dominate in these cells, and their stimulation is mainly associated with anti-inflammatory effects. Although the cholinergic modulation of mononuclear phagocytes is of eminent clinical relevance for the prevention and treatment of inflammatory diseases and neuropathic pain, we are only beginning to understand the underlying mechanisms on the molecular level. The purpose of this review is to report and critically discuss the current knowledge on signal transduction mechanisms elicited by nicotinic acetylcholine receptors in mononuclear phagocytes.http://www.sciencedirect.com/science/article/pii/S104366182300083XMonocytesMacrophagesDendritic cellsNicotinic acetylcholine receptorsSignal transductionIonotropic |
| spellingShingle | Katrin Richter Veronika Grau Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes Pharmacological Research Monocytes Macrophages Dendritic cells Nicotinic acetylcholine receptors Signal transduction Ionotropic |
| title | Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes |
| title_full | Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes |
| title_fullStr | Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes |
| title_full_unstemmed | Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes |
| title_short | Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes |
| title_sort | signaling of nicotinic acetylcholine receptors in mononuclear phagocytes |
| topic | Monocytes Macrophages Dendritic cells Nicotinic acetylcholine receptors Signal transduction Ionotropic |
| url | http://www.sciencedirect.com/science/article/pii/S104366182300083X |
| work_keys_str_mv | AT katrinrichter signalingofnicotinicacetylcholinereceptorsinmononuclearphagocytes AT veronikagrau signalingofnicotinicacetylcholinereceptorsinmononuclearphagocytes |