Radiogenomic analysis of primary breast cancer reveals [18F]-fluorodeoxglucose dynamic flux-constants are positively associated with immune pathways and outperform static uptake measures in associating with glucose metabolism

Radiogenomic analysis of primary breast cancer reveals [18F]-fluorodeoxglucose dynamic flux-constants are positively associated with immune pathways and outperform static uptake measures in associating with glucose metabolism

Abstract Background PET imaging of 18F-fluorodeoxygucose (FDG) is used widely for tumour staging and assessment of treatment response, but the biology associated with FDG uptake is still not fully elucidated. We therefore carried out gene set enrichment analyses (GSEA) of RNA sequencing data to find...

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Bibliographic Details
Main Authors: G. P. Ralli, R. D. Carter, D. R. McGowan, W.-C. Cheng, D. Liu, E. J. Teoh, N. Patel, F. Gleeson, A. L. Harris, S. R. Lord, F. M. Buffa, J. D. Fenwick
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Breast Cancer Research
Subjects:
Breast cancer
FDG-PET
RNA sequencing
GSEA
Glycolysis/gluconeogenesis
Immune pathways
Online Access:https://doi.org/10.1186/s13058-022-01529-9

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