Advances in understanding ischemic acute kidney injury
<p>Abstract</p> <p>Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusse...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-02-01
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| Series: | BMC Medicine |
| Online Access: | http://www.biomedcentral.com/1741-7015/9/11 |
| _version_ | 1828376973654622208 |
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| author | Himmelfarb Jonathan Hsu Christine Munshi Raj |
| author_facet | Himmelfarb Jonathan Hsu Christine Munshi Raj |
| author_sort | Himmelfarb Jonathan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic AKI pathophysiology, the emerging relationship between ischemic AKI and development of progressive chronic kidney disease, and promising novel therapies currently under investigation. On the basis of recent breakthroughs in understanding the pathophysiology of ischemic AKI, therapies that can treat or even prevent ischemic AKI may become a reality in the near future.</p> |
| first_indexed | 2024-04-14T08:07:58Z |
| format | Article |
| id | doaj.art-476cf55355b342289e419993d6e0a632 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-04-14T08:07:58Z |
| publishDate | 2011-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-476cf55355b342289e419993d6e0a6322022-12-22T02:04:41ZengBMCBMC Medicine1741-70152011-02-01911110.1186/1741-7015-9-11Advances in understanding ischemic acute kidney injuryHimmelfarb JonathanHsu ChristineMunshi Raj<p>Abstract</p> <p>Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic AKI pathophysiology, the emerging relationship between ischemic AKI and development of progressive chronic kidney disease, and promising novel therapies currently under investigation. On the basis of recent breakthroughs in understanding the pathophysiology of ischemic AKI, therapies that can treat or even prevent ischemic AKI may become a reality in the near future.</p>http://www.biomedcentral.com/1741-7015/9/11 |
| spellingShingle | Himmelfarb Jonathan Hsu Christine Munshi Raj Advances in understanding ischemic acute kidney injury BMC Medicine |
| title | Advances in understanding ischemic acute kidney injury |
| title_full | Advances in understanding ischemic acute kidney injury |
| title_fullStr | Advances in understanding ischemic acute kidney injury |
| title_full_unstemmed | Advances in understanding ischemic acute kidney injury |
| title_short | Advances in understanding ischemic acute kidney injury |
| title_sort | advances in understanding ischemic acute kidney injury |
| url | http://www.biomedcentral.com/1741-7015/9/11 |
| work_keys_str_mv | AT himmelfarbjonathan advancesinunderstandingischemicacutekidneyinjury AT hsuchristine advancesinunderstandingischemicacutekidneyinjury AT munshiraj advancesinunderstandingischemicacutekidneyinjury |