Elevated intramuscular adipose tissue content with a high Ishak fibrosis stage (>3) had a negative effect on liver regeneration in cirrhotic patients undergoing portal vein embolization
Abstract This study investigated the relationship between body composition parameters and changes in future liver remnant volume (FLRV) in hepatocellular carcinoma (HCC) patients undergoing portal vein embolization (PVE) in preparation for right hepatectomy. This retrospective study enrolled 21 pati...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-02-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/kjm2.12622 |
| _version_ | 1811168208712892416 |
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| author | Yu‐Ling Huang Meng‐Chuan Huang Chiao‐I Chang Li‐Hwa Yang Chia‐Jen Wu Chien‐Chih Chiu Chiao‐Yun Chen Jui‐Sheng Hsu King‐Teh Lee Wen‐Tsan Chang |
| author_facet | Yu‐Ling Huang Meng‐Chuan Huang Chiao‐I Chang Li‐Hwa Yang Chia‐Jen Wu Chien‐Chih Chiu Chiao‐Yun Chen Jui‐Sheng Hsu King‐Teh Lee Wen‐Tsan Chang |
| author_sort | Yu‐Ling Huang |
| collection | DOAJ |
| description | Abstract This study investigated the relationship between body composition parameters and changes in future liver remnant volume (FLRV) in hepatocellular carcinoma (HCC) patients undergoing portal vein embolization (PVE) in preparation for right hepatectomy. This retrospective study enrolled 21 patients between May 2013 and October 2020. Body composition parameters, including skeletal muscle attenuation (SMA), skeletal muscle mass index (SMI), intramuscular adipose tissue content (IMAC), and visceral‐to‐subcutaneous adipose tissue area ratio (VSR), were measured by computed tomography (CT) prior to PVE. Liver volumetry was measured before and at least 5 weeks after PVE. The mean interval between two CT volumetries was 9.1 ± 4.9 weeks, the mean value of increase in FLRV (ΔFLRV) was 236.0 ± 118.3 cm3, the ratio of increased FLRV (ΔFLRV%) was 55.7 ± 29.4%, and the rate of increased FLRV was 31.0 ± 18.8 (cm3/week). Subjects with high IMAC showed significantly lower (p = 0.044) ΔFLRV% than those with normal IMAC. Furthermore, ΔFLRV% was linearly reduced (p for trend = 0.043) among those with low Ishak fibrosis stage (<3) + normal IMAC (76.1 ± 36.8%), those with low Ishak fibrosis stage (<3) + high IMAC or high Ishak fibrosis stage (>3) + normal IMAC (54.0 ± 24.1%), and those with high Ishak fibrosis stage (>3) + low IMAC (28.7 ± 1.6%) (p for trend = 0.043). Our data indicated that high IMAC with a high Ishak fibrosis stage (>3) had a significant negative effect on ΔFLRV%. |
| first_indexed | 2024-04-10T16:22:15Z |
| format | Article |
| id | doaj.art-476db9fdb5d84590b7d4226ab86276eb |
| institution | Directory Open Access Journal |
| issn | 1607-551X 2410-8650 |
| language | English |
| last_indexed | 2024-04-10T16:22:15Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-476db9fdb5d84590b7d4226ab86276eb2023-02-09T11:38:14ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502023-02-0139218219010.1002/kjm2.12622Elevated intramuscular adipose tissue content with a high Ishak fibrosis stage (>3) had a negative effect on liver regeneration in cirrhotic patients undergoing portal vein embolizationYu‐Ling Huang0Meng‐Chuan Huang1Chiao‐I Chang2Li‐Hwa Yang3Chia‐Jen Wu4Chien‐Chih Chiu5Chiao‐Yun Chen6Jui‐Sheng Hsu7King‐Teh Lee8Wen‐Tsan Chang9Department of Medical Imaging Kaohsiung Medical University Hospital Kaohsiung TaiwanDepartment of Public Health and Environmental Medicine School of Medicine, College of Medicine, Kaohsiung Medical University Kaohsiung TaiwanDepartment of Public Health and Environmental Medicine School of Medicine, College of Medicine, Kaohsiung Medical University Kaohsiung TaiwanDepartment of Medical Imaging Kaohsiung Medical University Hospital Kaohsiung TaiwanDepartment of Medical Imaging Kaohsiung Medical University Hospital Kaohsiung TaiwanDepartment of Biotechnology College of Life Science, Kaohsiung Medical University Kaohsiung TaiwanDepartment of Medical Imaging Kaohsiung Medical University Hospital Kaohsiung TaiwanDepartment of Medical Imaging Kaohsiung Medical University Hospital Kaohsiung TaiwanDepartment of Surgery Park One International Hospital Kaohsiung TaiwanGraduate Institute of Clinical Medicine, College of Medicine Kaohsiung Medical University Kaohsiung TaiwanAbstract This study investigated the relationship between body composition parameters and changes in future liver remnant volume (FLRV) in hepatocellular carcinoma (HCC) patients undergoing portal vein embolization (PVE) in preparation for right hepatectomy. This retrospective study enrolled 21 patients between May 2013 and October 2020. Body composition parameters, including skeletal muscle attenuation (SMA), skeletal muscle mass index (SMI), intramuscular adipose tissue content (IMAC), and visceral‐to‐subcutaneous adipose tissue area ratio (VSR), were measured by computed tomography (CT) prior to PVE. Liver volumetry was measured before and at least 5 weeks after PVE. The mean interval between two CT volumetries was 9.1 ± 4.9 weeks, the mean value of increase in FLRV (ΔFLRV) was 236.0 ± 118.3 cm3, the ratio of increased FLRV (ΔFLRV%) was 55.7 ± 29.4%, and the rate of increased FLRV was 31.0 ± 18.8 (cm3/week). Subjects with high IMAC showed significantly lower (p = 0.044) ΔFLRV% than those with normal IMAC. Furthermore, ΔFLRV% was linearly reduced (p for trend = 0.043) among those with low Ishak fibrosis stage (<3) + normal IMAC (76.1 ± 36.8%), those with low Ishak fibrosis stage (<3) + high IMAC or high Ishak fibrosis stage (>3) + normal IMAC (54.0 ± 24.1%), and those with high Ishak fibrosis stage (>3) + low IMAC (28.7 ± 1.6%) (p for trend = 0.043). Our data indicated that high IMAC with a high Ishak fibrosis stage (>3) had a significant negative effect on ΔFLRV%.https://doi.org/10.1002/kjm2.12622future liver remnant volumeintramuscular adipose tissue contentliver regenerationportal vein embolizationsarcopenia |
| spellingShingle | Yu‐Ling Huang Meng‐Chuan Huang Chiao‐I Chang Li‐Hwa Yang Chia‐Jen Wu Chien‐Chih Chiu Chiao‐Yun Chen Jui‐Sheng Hsu King‐Teh Lee Wen‐Tsan Chang Elevated intramuscular adipose tissue content with a high Ishak fibrosis stage (>3) had a negative effect on liver regeneration in cirrhotic patients undergoing portal vein embolization Kaohsiung Journal of Medical Sciences future liver remnant volume intramuscular adipose tissue content liver regeneration portal vein embolization sarcopenia |
| title | Elevated intramuscular adipose tissue content with a high Ishak fibrosis stage (>3) had a negative effect on liver regeneration in cirrhotic patients undergoing portal vein embolization |
| title_full | Elevated intramuscular adipose tissue content with a high Ishak fibrosis stage (>3) had a negative effect on liver regeneration in cirrhotic patients undergoing portal vein embolization |
| title_fullStr | Elevated intramuscular adipose tissue content with a high Ishak fibrosis stage (>3) had a negative effect on liver regeneration in cirrhotic patients undergoing portal vein embolization |
| title_full_unstemmed | Elevated intramuscular adipose tissue content with a high Ishak fibrosis stage (>3) had a negative effect on liver regeneration in cirrhotic patients undergoing portal vein embolization |
| title_short | Elevated intramuscular adipose tissue content with a high Ishak fibrosis stage (>3) had a negative effect on liver regeneration in cirrhotic patients undergoing portal vein embolization |
| title_sort | elevated intramuscular adipose tissue content with a high ishak fibrosis stage 3 had a negative effect on liver regeneration in cirrhotic patients undergoing portal vein embolization |
| topic | future liver remnant volume intramuscular adipose tissue content liver regeneration portal vein embolization sarcopenia |
| url | https://doi.org/10.1002/kjm2.12622 |
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