Prognostic value of myopic disk deformation in myopic choroidal neovascularization: A 6-year follow-up study
PurposeTo evaluate the clinical characteristics of myopic choroidal neovascularization (mCNV) according to peripapillary atrophy (PPA) and optic disk tilt and to explore whether those myopic disk deformations are associated with the prognosis of mCNV.MethodsPatients with subfoveal mCNV who received...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.947632/full |
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| author | Ye Eun Han Yoon Jeon Kim Hyun Seung Yang Byung Gill Moon Joo Yong Lee June-Gone Kim Young Hee Yoon |
| author_facet | Ye Eun Han Yoon Jeon Kim Hyun Seung Yang Byung Gill Moon Joo Yong Lee June-Gone Kim Young Hee Yoon |
| author_sort | Ye Eun Han |
| collection | DOAJ |
| description | PurposeTo evaluate the clinical characteristics of myopic choroidal neovascularization (mCNV) according to peripapillary atrophy (PPA) and optic disk tilt and to explore whether those myopic disk deformations are associated with the prognosis of mCNV.MethodsPatients with subfoveal mCNV who received intravitreal bevacizumab injection and followed for ≥3 years were included. PPA was quantified as area of the ß-zone PPA/disk area ratio (PDR) and optic disk tilt as the tilt ratio (the longest/shortest disk diameter). We compared the clinical characteristics in terms of PDR and tilt ratio and identified the poor prognostic factors using Logistic regression and Cox proportional hazard model.ResultsAmong 80 eyes of 80 patients, 29 (36.30%) eyes developed macular atrophy during 80.71 ± 34.76 months. PDR and tilt ratio are strongly correlated with each other (P = 0.004). Higher PDR showed significant correlations with longer axial length (P = 0.013), worse baseline and final VA (P = 0.007 and P = 0.047), and thinner subfoveal choroidal thickness (P = 0.039), while higher tilt ratio showed significant correlations only with longer axial length (P = 0.036). High PDR was also an independent risk factor for both macular atrophy (OR = 2.257, P < 0.001) and poor visual outcome (HR = 1.174, P = 0.007), while high disk tilt ratio was not.ConclusionSubfoveal mCNV with higher ß-zone PPA area/disk area ratio had worse functional and structural outcomes. |
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| last_indexed | 2024-12-11T21:21:21Z |
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| series | Frontiers in Medicine |
| spelling | doaj.art-476e1adeecf645e4bef0245d8da07ca12022-12-22T00:50:27ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-08-01910.3389/fmed.2022.947632947632Prognostic value of myopic disk deformation in myopic choroidal neovascularization: A 6-year follow-up studyYe Eun Han0Yoon Jeon Kim1Hyun Seung Yang2Byung Gill Moon3Joo Yong Lee4June-Gone Kim5Young Hee Yoon6Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaDepartment of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaDepartment of Ophthalmology, Seoul Shinsegae Eye Center, Eui Jung Bu, South KoreaDepartment of Ophthalmology, Seoul Shinsegae Eye Center, Eui Jung Bu, South KoreaDepartment of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaDepartment of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaDepartment of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaPurposeTo evaluate the clinical characteristics of myopic choroidal neovascularization (mCNV) according to peripapillary atrophy (PPA) and optic disk tilt and to explore whether those myopic disk deformations are associated with the prognosis of mCNV.MethodsPatients with subfoveal mCNV who received intravitreal bevacizumab injection and followed for ≥3 years were included. PPA was quantified as area of the ß-zone PPA/disk area ratio (PDR) and optic disk tilt as the tilt ratio (the longest/shortest disk diameter). We compared the clinical characteristics in terms of PDR and tilt ratio and identified the poor prognostic factors using Logistic regression and Cox proportional hazard model.ResultsAmong 80 eyes of 80 patients, 29 (36.30%) eyes developed macular atrophy during 80.71 ± 34.76 months. PDR and tilt ratio are strongly correlated with each other (P = 0.004). Higher PDR showed significant correlations with longer axial length (P = 0.013), worse baseline and final VA (P = 0.007 and P = 0.047), and thinner subfoveal choroidal thickness (P = 0.039), while higher tilt ratio showed significant correlations only with longer axial length (P = 0.036). High PDR was also an independent risk factor for both macular atrophy (OR = 2.257, P < 0.001) and poor visual outcome (HR = 1.174, P = 0.007), while high disk tilt ratio was not.ConclusionSubfoveal mCNV with higher ß-zone PPA area/disk area ratio had worse functional and structural outcomes.https://www.frontiersin.org/articles/10.3389/fmed.2022.947632/fullmyopic choroidal neovascularizationmyopic disc deformationβ-zone peripapillary atrophyoptic disc tiltdegenerative myopia |
| spellingShingle | Ye Eun Han Yoon Jeon Kim Hyun Seung Yang Byung Gill Moon Joo Yong Lee June-Gone Kim Young Hee Yoon Prognostic value of myopic disk deformation in myopic choroidal neovascularization: A 6-year follow-up study Frontiers in Medicine myopic choroidal neovascularization myopic disc deformation β-zone peripapillary atrophy optic disc tilt degenerative myopia |
| title | Prognostic value of myopic disk deformation in myopic choroidal neovascularization: A 6-year follow-up study |
| title_full | Prognostic value of myopic disk deformation in myopic choroidal neovascularization: A 6-year follow-up study |
| title_fullStr | Prognostic value of myopic disk deformation in myopic choroidal neovascularization: A 6-year follow-up study |
| title_full_unstemmed | Prognostic value of myopic disk deformation in myopic choroidal neovascularization: A 6-year follow-up study |
| title_short | Prognostic value of myopic disk deformation in myopic choroidal neovascularization: A 6-year follow-up study |
| title_sort | prognostic value of myopic disk deformation in myopic choroidal neovascularization a 6 year follow up study |
| topic | myopic choroidal neovascularization myopic disc deformation β-zone peripapillary atrophy optic disc tilt degenerative myopia |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.947632/full |
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