cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity

cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity

Porcine reproductive and respiratory syndrome virus (PRRSV) is an RNA virus that causes great economic losses globally to the swine industry. Innate immune RNA receptors mainly sense it during infection. As a DNA sensor, cyclic GMP-AMP synthase (cGAS) plays an important role in sensing cytosolic DNA...

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Bibliographic Details
Main Authors: Xiao-Na Liu, Li-Wei Li, Fei Gao, Yi-Feng Jiang, Wan-Zhe Yuan, Guo-Xin Li, Ling-Xue Yu, Yan-Jun Zhou, Guang-Zhi Tong, Kuan Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
PRRSV
cGAS
mtDNA
cGAMP
replication
antiviral activity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.887054/full

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